El-Aziz Rokaya Abd, Alnaggar Alshaimaa Rezk L R, Mohamed Nabih Mona Ibrahim, Ali Shaimaa Mohammed, Khattab Hany, El-Atty Sahar Abd
Internal Medicine Department, Kasr Alainy Hospital, Faculty of Medicine, Cairo University, Egypt.
Pathology Department, Kasr Alainy Hospital, Faculty of Medicine, Cairo University, Egypt.
Clin Exp Hepatol. 2020 Feb;6(1):28-34. doi: 10.5114/ceh.2020.93053. Epub 2020 Feb 17.
This study aimed to assess the level of serum Mac-2 binding protein (Mac-2BP) as a non-invasive biomarker for the diagnosis of non-alcoholic fatty liver disease (NAFLD).
Forty patients with NAFLD and 15 healthy sex- and age-matched subjects were included in this pilot study. Serum Mac-2BP level was measured using ELISA. Liver biopsy was taken from 20 patients.
There was no statistically significant difference between patients and controls regarding the level of Mac-2BP ( = 0.209) Mac-2BP had a statistically significant correlation with the grade of lobular inflammation ( = 0464, = 0.039). The Mac-2BP cut-off value used for NASH prediction was 9.55 µg/ml, with sensitivity and specificity of 100% and 91.7%, respectively.
This study showed that Mac-2BP is not elevated in NAFLD patients compared to controls. It also demonstrated that the reliability of Mac-2BP as a biomarker for NAFLD diagnosis is still controversial and needs more investigation.
本研究旨在评估血清Mac-2结合蛋白（Mac-2BP）水平作为非酒精性脂肪性肝病（NAFLD）诊断的非侵入性生物标志物。
本初步研究纳入了40例NAFLD患者和15例年龄及性别匹配的健康受试者。采用酶联免疫吸附测定法（ELISA）检测血清Mac-2BP水平。对20例患者进行了肝活检。
患者与对照组之间Mac-2BP水平差异无统计学意义（P = 0.209）。Mac-2BP与小叶炎症分级具有统计学意义的相关性（P = 0.464，P = 0.039）。用于非酒精性脂肪性肝炎（NASH）预测的Mac-2BP临界值为9.55μg/ml，敏感性和特异性分别为100%和91.7%。
本研究表明，与对照组相比，NAFLD患者的Mac-2BP未升高。研究还表明，Mac-2BP作为NAFLD诊断生物标志物的可靠性仍存在争议，需要更多研究。
