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干细胞在神经再生中的效用。

The utility of stem cells for neural regeneration.

作者信息

Goncalves Kirsty, Przyborski Stefan

机构信息

Department of Biosciences, Durham University, Durham, UK.

Reprocell Europe, Sedgefield, UK.

出版信息

Brain Neurosci Adv. 2018 Dec 5;2:2398212818818071. doi: 10.1177/2398212818818071. eCollection 2018 Jan-Dec.

Abstract

The use of stem cells in biomedical research is an extremely active area of science. This is because they provide tools that can be used both in vivo and vitro to either replace cells lost in degenerative processes, or to model such diseases to elucidate their underlying mechanisms. This review aims to discuss the use of stem cells in terms of providing regeneration within the nervous system, which is particularly important as neurons of the central nervous system lack the ability to inherently regenerate and repair lost connections. As populations are ageing, incidence of neurodegenerative diseases are increasing, highlighting the need to better understand the regenerative capacity and many uses of stem cells in this field.

摘要

干细胞在生物医学研究中的应用是一个极其活跃的科学领域。这是因为它们提供了可在体内和体外使用的工具,用于替代在退行性过程中丢失的细胞,或对这类疾病进行建模以阐明其潜在机制。本综述旨在讨论干细胞在神经系统内提供再生方面的应用,这一点尤为重要,因为中枢神经系统的神经元本身缺乏再生和修复失去连接的能力。随着人口老龄化,神经退行性疾病的发病率不断上升,凸显了更好地了解干细胞在该领域的再生能力和多种用途的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8032/7058206/6c30da27797c/10.1177_2398212818818071-fig1.jpg

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