Brown S A, Schuckit M A
Veterans Administration Medical Center, San Diego, California 92161.
J Stud Alcohol. 1988 Sep;49(5):412-7. doi: 10.15288/jsa.1988.49.412.
The rate and pattern of change in depressive symptoms among male primary alcoholics (no preexisting major psychiatric disorder) were studied throughout inpatient treatment for alcoholism. A sample of 191 alcoholics was interviewed with the Hamilton Depression Rating Scale within 48 hours of admission and again at each of the 4 weeks of treatment. Results indicate that 42% of alcoholics have clinically significant levels of depression (Hamilton greater than or equal to 20) at intake but only 6% remain clinically depressed at Week 4. Depressive symptoms of alcoholics abate quickly with the largest reduction in scores at Week 2. Mood related symptoms constitute the largest portion of presenting depression and abate most rapidly. Vegetative symptoms remain the most prevalent type of depressive symptom at discharge. Results suggest that antidepressant medication should not be considered prior to 4 weeks of abstinence.
在整个酒精中毒住院治疗期间，对男性原发性酒精中毒患者（无既往重大精神疾病）抑郁症状的变化率和模式进行了研究。对191名酒精中毒患者样本在入院后48小时内使用汉密尔顿抑郁量表进行访谈，并在治疗的第4周每周再次访谈。结果表明，42%的酒精中毒患者在入院时临床上有显著程度的抑郁（汉密尔顿评分大于或等于20），但在第4周时只有6%仍有临床抑郁症状。酒精中毒患者的抑郁症状迅速减轻，在第2周时得分下降幅度最大。与情绪相关的症状在出现的抑郁症状中占最大比例，且减轻速度最快。植物神经症状在出院时仍是最普遍的抑郁症状类型。结果表明，在戒酒4周之前不应考虑使用抗抑郁药物。
