Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Gyeonggi-do, Republic of Korea.
Department of Orthopaedic Surgery, Yongin Severance Hospital, Yonsei University College of Medicine, Gyeonggi-do, Republic of Korea.
Arch Osteoporos. 2020 Mar 12;15(1):43. doi: 10.1007/s11657-020-0700-4.
In two population-based study of middle-aged and older people, we investigated if platelet count was associated with bone mineral density and determined whether the association remained over time. Highest platelet counts within the normal range are significantly associated with osteopenia and osteoporosis in middle-aged and elderly people.
Recently, platelets were found to play a role in bone remodeling. However, data on the association between platelet count and osteoporosis are lacking. Our study aimed to investigate the association between platelet counts, osteopenia, and osteoporosis in middle-aged and elderly Koreans.
We analyzed cross-sectional data from 5181 adults (postmenopausal women and men over 50 years of age) in the 2008-2011 Korea National Health and Nutrition Examination Survey (KNHANES) and longitudinal prospective data from 3312 adults over 50 years of age in the Korean Genome and Epidemiology Study (KoGES). Bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry in the KNHANES and quantitative ultrasound in the KoGES. The platelet counts were categorized into quintiles within normal ranges (150-450 × 10 μL). The associations between platelet counts, osteopenia, and osteoporosis were estimated using a multinomial logistic model.
BMD of the femur neck, total femur, and lumbar spine all decreased with increasing platelet counts. The cut-off points of the platelet counts to differentiate normal BMD from osteopenia and osteopenia from osteoporosis were 217 × 10/μL and 269 × 10/μL, respectively. The odds ratios (95% confidence intervals) in the highest platelet quartile were 1.39 (1.03-1.88) for osteopenia and 1.60 (1.07-2.37) for osteoporosis after adjusting for confounding factors. The distal radius T-score was significantly decreased in the highest platelet tertile group at a follow-up of 10 years.
Highest platelet counts within the normal range are significantly associated with osteopenia and osteoporosis in middle-aged and elderly people.
在两项基于人群的中年和老年人研究中，我们调查了血小板计数是否与骨密度有关，并确定了这种关联是否随着时间的推移而持续。正常范围内的最高血小板计数与中年和老年人的骨质疏松症和骨量减少显著相关。
最近发现血小板在骨重塑中起作用。然而，关于血小板计数与骨质疏松症之间的关系的数据尚缺乏。我们的研究旨在调查中年和老年韩国人中血小板计数、骨质疏松症和骨量减少之间的关系。
我们分析了 2008-2011 年韩国国家健康和营养检查调查（KNHANES）中 5181 名成年人（绝经后妇女和 50 岁以上男性）的横断面数据，以及韩国基因组和流行病学研究（KoGES）中 3312 名 50 岁以上成年人的前瞻性纵向数据。KNHANES 采用双能 X 射线吸收法测量骨矿物质密度（BMD），KoGES 采用定量超声法测量。血小板计数在正常范围内（150-450×10μL）分为五组。使用多项逻辑回归模型估计血小板计数、骨质疏松症和骨量减少之间的关系。
股骨颈、全股骨和腰椎的 BMD 均随血小板计数的增加而降低。将血小板计数的截止值定义为区分正常 BMD 与骨质疏松症和骨质疏松症与骨量减少的分界点分别为 217×10/μL 和 269×10/μL。在调整混杂因素后，最高血小板四分位组的骨质疏松症比值比（95%置信区间）为 1.39（1.03-1.88），骨质疏松症为 1.60（1.07-2.37）。在 10 年的随访中，最高血小板三分位组的远端桡骨 T 评分显著降低。
正常范围内的最高血小板计数与中年和老年人的骨质疏松症和骨量减少显著相关。
Zotero 插件