Department of Food and Nutrition, Wonkwang University, 460 Iksandaero, Iksan, Jeonbuk 54538, Korea.
Cancer Prevention and Control Program, University of South Carolina, Columbia, SC 29208, USA.
Nutrients. 2019 Apr 19;11(4):885. doi: 10.3390/nu11040885.
Post menopause is considered a critical period for bone-mass loss. Impaired bone metabolism during this phase can increase the risk of fractures in old age. Inflammation is a risk factor for bone health, and diet is a potential source of inflammation. However, few studies have examined the association between the dietary inflammatory index (DII) and bone-mineral density (BMD) in postmenopausal women in Korea. The objective of this study was to determine, by means of a Korean cross-sectional investigation, whether higher DII scores are associated with decreased BMD in postmenopausal women. To that end, the raw data from the fourth and fifth Korea National Health and Nutrition Examination Surveys (KNHANES, 2009-2011) for 2778 postmenopausal women aged over 50 years were analyzed. The subjects' BMD were measured by dual-energy x-ray absorptiometry, and their DII scores were calculated from a single 24-h dietary recall. Further, the participants were classified into three groups according to DII score. Women with more pro-inflammatory diets (i.e., those in the highest tertile of DII) had significantly lower BMD in the femoral neck as compared with women in the lowest tertile ( for trend <0.05) after adjustment for age, body-mass index (BMI), household income, education status, smoking habits, physical activity, total calcium intake, female-hormone use, age at menopause, and blood vitamin D levels. Multiple logistic regression analyses revealed that the odds ratio (OR) of total femur osteopenia/osteoporosis was higher in women in the highest tertile of DII than in those in the lowest (OR 1.27, 95% CI 1.00-1.62, for trend < 0.05). This study established that more pro-inflammatory diets might be associated with lower BMD in postmenopausal Korean women.
绝经后被认为是骨质流失的关键时期。在此期间，骨骼代谢受损会增加老年时骨折的风险。炎症是骨骼健康的一个危险因素，而饮食是炎症的潜在来源。然而，很少有研究调查过韩国绝经后妇女饮食炎症指数（DII）与骨矿物质密度（BMD）之间的关系。本研究旨在通过韩国横断面调查，确定较高的 DII 评分是否与绝经后妇女的 BMD 降低有关。为此，分析了第四次和第五次韩国国家健康和营养检查调查（KNHANES，2009-2011 年）中 2778 名年龄在 50 岁以上的绝经后妇女的原始数据。通过双能 X 射线吸收法测量受试者的 BMD，根据单次 24 小时膳食回忆计算 DII 评分。此外，根据 DII 评分将参与者分为三组。与 DII 评分最低组相比，饮食中促炎成分较多（即 DII 评分最高三分位组）的女性股骨颈 BMD 明显较低（趋势检验<0.05），调整年龄、体重指数（BMI）、家庭收入、教育程度、吸烟习惯、身体活动、总钙摄入量、激素使用、绝经年龄和血液维生素 D 水平后。多因素逻辑回归分析显示，DII 评分最高组女性全股骨骨质疏松/骨量减少的比值比（OR）高于 DII 评分最低组（OR 1.27，95%CI 1.00-1.62，趋势检验<0.05）。本研究表明，促炎饮食可能与绝经后韩国女性的 BMD 降低有关。
