Division of Thoracic Surgery, Shizuoka Cancer Center, Shimonagakubo 1007, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan.
Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
Gen Thorac Cardiovasc Surg. 2020 Dec;68(12):1547-1550. doi: 10.1007/s11748-020-01329-y. Epub 2020 Mar 12.
Two women in their sixties were diagnosed with inoperable locally advanced epithelioid malignant pleural mesothelioma, c-stage IIIB. Post-chemotherapy, the tumors down-staged to yc-stage IA, and pleurectomy/decortication were performed. The pathological diagnoses were p-stages II and IA. One patient had tumor recurrence 6 months after surgery; she is currently undergoing fourth-line chemotherapy and is alive 30 months postoperatively. The second patient had tumor recurrence 4 months after surgery and died 2 months later. Conversion surgery for advanced malignant mesothelioma does not improve progression-free survival but might have a chance to extend overall survival in selected patients without deteriorating performance status.
两位六十多岁的女性被诊断为不能手术的局部晚期上皮样恶性胸膜间皮瘤，c 期 IIIB 期。化疗后，肿瘤降期为 yc 期 IA 期，并进行了胸膜切除术/剥脱术。病理诊断为 p 期 II 期和 IA 期。一位患者在手术后 6 个月肿瘤复发；她目前正在接受四线化疗，手术后 30 个月仍存活。第二位患者在手术后 4 个月肿瘤复发，2 个月后死亡。对于晚期恶性间皮瘤，转换手术并不能改善无进展生存期，但在不恶化功能状态的情况下，可能有机会延长某些患者的总生存期。
