School of Medicine, Nantong University, Nantong, Jiangsu, PR China.
Information Department, The Third People's Hospital of Nantong, Nantong, Jiangsu, PR China.
Nutr Clin Pract. 2020 Dec;35(6):1001-1009. doi: 10.1002/ncp.10485. Epub 2020 Mar 13.
The aim of this systematic review was to summarize the evidence on the efficacy of zinc supplementation in patients with pressure injuries (PIs). Electronic data bases (Embase, MEDLINE, and Web of Science) were searched from inception to 2019 for randomized controlled trials (RCTs) and non-RCTs addressing the efficacy of zinc supplementation compared with a control nutrition invention on PI outcomes. The primary study outcome was the healing rate of PIs during treatment; the secondary outcomes were the improvement of PI area and pressure ulcer scale for healing (PUSH) score. A total of 7 studies were included in this systematic review and meta-analysis. The intervention group significantly had improved healing vs that of the control group (relative risk, 1.44; 95% CI, 1.01-2.06; P = 0.043, I = 19.3%). There was no obvious asymmetry in the funnel plot and no strong evidence of publication bias. Sensitivity analysis showed that meta-analysis has good stability. Studies showed a greater mean reduction in PI area. All the studies we included had a significant improvement in the PUSH score of PIs. Our systematic review and meta-analysis from clinical research confirmed that zinc therapy can promote wound healing and suggest that medical staff should consider providing patients with zinc during PI treatment.
本系统评价的目的是总结锌补充剂在压疮（PI）患者中的疗效证据。从建库到 2019 年，我们在电子数据库（Embase、MEDLINE 和 Web of Science）中搜索了比较锌补充剂与对照营养发明对 PI 结局影响的随机对照试验（RCT）和非 RCT。主要研究结果是治疗期间 PI 的愈合率；次要结果是 PI 面积和压疮愈合评分（PUSH）的改善。本系统评价和荟萃分析共纳入 7 项研究。干预组的愈合率明显高于对照组（相对风险，1.44；95%CI，1.01-2.06；P = 0.043，I = 19.3%）。漏斗图无明显不对称，无发表偏倚的强烈证据。敏感性分析表明荟萃分析具有良好的稳定性。研究表明，PI 面积的平均减少更大。我们纳入的所有研究都显著提高了 PUSH 评分。我们的临床研究系统评价和荟萃分析证实，锌治疗可以促进伤口愈合，并提示医务人员在治疗 PI 时应考虑为患者提供锌。
