Department of Gastrointestinal Surgery II, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.
Department of Radio-Oncology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, 215001, China.
Epigenomics. 2020 Jun;12(11):907-920. doi: 10.2217/epi-2020-0036. Epub 2020 Mar 13.
To identify methylation-driven genes and establish a novel epigenetic signature for gastrointestinal (GI) pan-adenocarcinomas. Methylation and RNA-seq data for GI adenocarcinomas were downloaded from the Cancer Genome Atlas database. A methylation-driven gene signature was established by multivariate Cox regression analysis. We developed a prognostic nomogram using a combination of methylation-driven gene risk score and clinicopathological variables. A joint survival analysis based on gene expression and methylation was conducted to further investigate the prognostic role of methylation-driven genes. An epigenetic signature was established based on five methylation-driven genes. We also established a prognostic nomogram based on methylation-driven gene risk score and clinicopathologic factors, with a favorable predictive ability. Joint survival analysis revealed that 28 methylation-driven genes could be independent prognostic factors for overall survival for GI adenocarcinomas. An epigenetic signature was established that effectively predicts the overall survival for GI adenocarcinomas across anatomic boundaries.
为了鉴定甲基化驱动基因并建立胃肠道（GI）多腺癌的新型表观遗传特征。从癌症基因组图谱数据库中下载了胃肠道腺癌的甲基化和 RNA-seq 数据。通过多元 Cox 回归分析建立了甲基化驱动基因特征。我们使用甲基化驱动基因风险评分和临床病理变量的组合开发了一个预后列线图。基于基因表达和甲基化的联合生存分析进一步研究了甲基化驱动基因的预后作用。基于五个甲基化驱动基因建立了一个表观遗传特征。我们还建立了基于甲基化驱动基因风险评分和临床病理因素的预后列线图，具有良好的预测能力。联合生存分析显示，28 个甲基化驱动基因可作为胃肠道腺癌总生存的独立预后因素。建立了一种表观遗传特征，可有效预测跨解剖边界的胃肠道腺癌总生存。
