Department of Blood Transfusion, The Second Hospital of Shanxi Medical University, Taiyuan, China.
Department of Orthopaedic Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, China.
Orthop Surg. 2020 Apr;12(2):450-456. doi: 10.1111/os.12628. Epub 2020 Mar 13.
To investigate the relationship between primary femoral head necrosis (ONFH) and an ABO blood group.
This study was a retrospective case-control trial. An analysis of the clinical data of an ABO blood group with 516 patients (case group) with ONFH and 489 limb-fracture patients (control group) without previous hip pain was obtained from the Second Hospital of Shanxi Medical University from November 2015 to November 2018. The clinical data included gender, age, height, weight, a history of smoking, alcohol abuse, prior medical history, hormone use, and ABO blood type. A logistic regression model was used for univariate and multivariate analysis.
From November 2015 to November 2018, there were 267 males and 249 females in the 516 cases of ONFH in the case group. The control group included 289 males and 200 females. In terms of age, the average age of the case group was significantly lower than that of the control group. In terms of body mass index (BMI), the BMI of the case group was significantly higher than that of the control group (P < 0.05). From the previous medical history of patients in the two groups (coronary heart disease, hypertension, cerebrovascular disease, diabetes, and peripheral vascular disease), there was no significant difference between the two groups from a statistical perspective (P < 0.05). However, according to the risk factors of ONFH (smoking, alcohol abuse, hyperlipidemia, and hormone-use history), there were significant differences between the case group and the control group. There was no statistical difference in the quantitative distribution ratio of the four blood types - A, B, O, and AB - between the case group and the control group. The outcomes of logistic multiple regression analysis presented that there was no significant correlation between the occurrence of ONFH and blood type A, B, AB, and O (P > 0.05). However, there are significant differences in the disease progression between the different blood types. There was a significant difference in the progression of disease between type A and type O. Among them, patients with ONFH and type A blood had the fastest progression with an average of 2.318 years, and the slowest progression was found in type O blood with an average of 5.15 years.
The ABO blood group has no correlation with the occurrence of ONFH, but the ABO blood type is closely related to the disease progression of ONFH.
探讨原发性股骨头坏死（ONFH）与 ABO 血型的关系。
本研究为回顾性病例对照研究。分析了 2015 年 11 月至 2018 年 11 月山西医科大学第二医院收治的 516 例股骨头坏死患者（病例组）和 489 例无髋关节疼痛病史的肢体骨折患者（对照组）的 ABO 血型临床资料。临床资料包括性别、年龄、身高、体重、吸烟史、酗酒史、既往病史、激素使用情况和 ABO 血型。采用单因素和多因素 logistic 回归模型进行分析。
病例组 516 例 ONFH 患者中，男 267 例，女 249 例；对照组中男 289 例，女 200 例。在年龄方面，病例组平均年龄明显低于对照组；在体重指数（BMI）方面，病例组 BMI 明显高于对照组（P<0.05）。从两组患者的既往病史（冠心病、高血压、脑血管病、糖尿病、外周血管病）来看，两组之间无统计学差异（P<0.05）。但是，根据 ONFH 的危险因素（吸烟、酗酒、高脂血症、激素使用史），病例组与对照组之间存在显著差异。病例组和对照组的四种血型（A、B、O 和 AB）的定量分布比例无统计学差异。logistic 多因素回归分析结果表明，ONFH 的发生与血型 A、B、AB 和 O 无显著相关性（P>0.05）。但是，不同血型之间的疾病进展存在显著差异。A 型和 O 型之间的疾病进展有显著差异。其中，A 型 ONFH 患者的疾病进展最快，平均为 2.318 年，O 型患者的疾病进展最慢，平均为 5.15 年。
ABO 血型与 ONFH 的发生无相关性，但 ABO 血型与 ONFH 的疾病进展密切相关。
