中性粒细胞水平与股骨头坏死的相关性分析。
Correlational analysis between neutrophil granulocyte levels and osteonecrosis of the femoral head.
机构信息
Department of Orthopedics, the First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, No. 17 Yongwaizheng Street, Nanchang City, Jiangxi Province, China.
出版信息
BMC Musculoskelet Disord. 2019 Aug 31;20(1):393. doi: 10.1186/s12891-019-2778-7.
BACKGROUND
The correlation between peripheral blood neutrophil level and osteonecrosis of the femoral head (ONFH) has not been extensively studied. Thus, we aimed to investigate the correlation between neutrophil level in the peripheral blood (neutrophil granulocyte) and ONFH.
METHODS
A total of 984 cases of ONFH and femoral neck fractures (non-ONFH) diagnosed at the Department of Orthopedics at our institution between January 1, 2011 and December 31, 2016 were retrospectively reviewed. The ONFH and non-ONFH groups comprised 488 and 496 cases, respectively. Basic information and peripheral blood cell levels of the two groups were compared.
RESULTS
The patients' mean age was 59.89 ± 17.06 years (range: 38-82 years). There were 457 male and 527 female patients, with a male-to-female ratio of 1:1.15. We found that neutrophil granulocyte levels and percentage of neutrophil granulocytes were significantly different between the ONFH and non-ONFH groups. Multimodal regression analysis showed that the percentage of neutrophil granulocytes was an independent protective factor against ONFH.
CONCLUSIONS
The factors influencing ONFH are neutrophil granulocyte levels and percentage of neutrophil granulocytes. Percentage of neutrophil granulocytes has a significant correlation with aseptic femoral head necrosis, providing a new perspective and direction for further study of femoral head necrosis.
背景
外周血中性粒细胞水平与股骨头坏死（ONFH）之间的相关性尚未得到广泛研究。因此，我们旨在研究外周血中性粒细胞（中性粒细胞）水平与 ONFH 之间的相关性。
方法
回顾性分析 2011 年 1 月 1 日至 2016 年 12 月 31 日我院骨科收治的 984 例 ONFH 和股骨颈骨折（非 ONFH）患者的临床资料。ONFH 和非 ONFH 组分别为 488 例和 496 例。比较两组患者的基本资料和外周血细胞水平。
结果
患者平均年龄为 59.89±17.06 岁（范围：38-82 岁）；其中男性 457 例，女性 527 例，男女比例为 1:1.15。我们发现 ONFH 组和非 ONFH 组的中性粒细胞水平和中性粒细胞百分比差异有统计学意义。多因素回归分析显示，中性粒细胞百分比是预防 ONFH 的独立保护因素。
结论
影响 ONFH 的因素是中性粒细胞水平和中性粒细胞百分比。中性粒细胞百分比与无菌性股骨头坏死有显著相关性，为股骨头坏死的进一步研究提供了新的视角和方向。
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