Meng Xian-Yue, Huang An-Qi, Khan Afsar, Zhang Li, Sun Xiao-Qian, Song Hao, Han Jun, Sun Qian-Ru, Wang Yu-Dan, Li Xue-Li
Department of Neurology, Liaocheng People's Hospital and Liaocheng School of Clinical Medicine, Taishan Medical University, Liaocheng, China.
Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan.
Chem Biol Drug Des. 2020 Jun;95(6):631-639. doi: 10.1111/cbdd.13681. Epub 2020 Mar 29.
Vascular endothelial growth factor (VEGF) had neuroprotective effects on dopaminergic (DA) neurons. In order to overcome the gastrointestinal digestion and bioaccessibility, VEGF was encapsulated with poly-lactic-co-glycolic acid nanospheres (NS) in order to prevent the VEGF degradation until its release. The caudal administration of VEGF and NS encapsulated VEGF at different doses (1.0, 10.0, and 100.0 ng/ml) on the rats with Parkinson's disease lesion was evaluated. Intravenous injected VEGF at the dose of 1 ng/ml displayed the strongest neuroprotective effect than other groups as well as the stereotaxic group. The NS encapsulated with VEGF can pass through blood-brain barrier and protect the DA neurons. There was no significant difference between intravenous injection method and stereotaxic method, while the first method is simpler and convenient. Injection of NS encapsulated with VEGF may become a valuable neurorescuing therapeutic approach for Parkinson's disease.
血管内皮生长因子（VEGF）对多巴胺能（DA）神经元具有神经保护作用。为了克服胃肠道消化和生物可及性问题，VEGF被包裹在聚乳酸-乙醇酸纳米球（NS）中，以防止VEGF降解直至其释放。评估了在帕金森病损伤大鼠中以不同剂量（1.0、10.0和100.0 ng/ml）尾静脉注射VEGF和NS包裹的VEGF的情况。静脉注射1 ng/ml剂量的VEGF显示出比其他组以及立体定位组更强的神经保护作用。VEGF包裹的NS能够穿过血脑屏障并保护DA神经元。静脉注射法和立体定位法之间没有显著差异，而第一种方法更简单方便。注射VEGF包裹的NS可能成为一种有价值的帕金森病神经挽救治疗方法。
