LED 光生物调节疗法治疗膝骨关节炎的疗效：一项大鼠研究。
Effectiveness of Led Photobiomodulation Therapy on Treatment With Knee Osteoarthritis: A Rat Study.
机构信息
From the Institute of Science and Technology of Brasil University, São Paulo, SP, Brazil (EST, LA, JCT, SS, LdS, CRT); and Physiotherapy Department, Federal University of São Carlos, São Paulo, Brazil (CCSM, RL).
出版信息
Am J Phys Med Rehabil. 2020 Aug;99(8):725-732. doi: 10.1097/PHM.0000000000001408.
OBJECTIVE
The present study aimed to evaluate the effectiveness of photobiomodulation therapy by light-emitting diode on osteoarthritis treatment in the knees of rats.
DESIGN
Twenty male Wistar rats were randomly assigned into two experimental groups: OAC: animals subjected to induction of osteoarthritis, without therapeutic intervention and the group OAL: animals subjected to induction of osteoarthritis treated with light-emitting diode photobiomodulation therapy (850 nm, 200 mW, 6 J).
RESULTS
The results of gait analysis showed no statistical difference between the groups. The histological findings showed that the OAL group presented abnormal chondrocyte orientation, yet with less irregularities along fibrillation and the joint tissue. Thus, it presented a lower degenerative process when evaluated by the Osteoarthritis Research Society International. Likewise, in the immunohistochemical analysis, the OAL group showed higher collagen 2 and transforming growth factor β immunoexpression when compared with the OAC group.
CONCLUSIONS
Given the above, it is possible to suggest that the photobiomodulation therapy by light-emitting diode had positive effects on the expression of extracellular matrix proteins responsible for synthesis of articular tissue.
目的
本研究旨在评估发光二极管光生物调节疗法对大鼠膝关节骨关节炎治疗的效果。
设计
20 只雄性 Wistar 大鼠随机分为两组：OA-C 组：骨关节炎诱导但未进行治疗干预的动物；OA-L 组：骨关节炎诱导并接受发光二极管光生物调节疗法（850nm，200mW，6J）治疗的动物。
结果
步态分析结果显示两组之间无统计学差异。组织学检查结果显示，OA-L 组的软骨细胞排列异常，但在纤维断裂和关节组织方面不规则程度较轻，因此其退行性过程的评估结果优于 OA-C 组。同样，在免疫组织化学分析中，与 OA-C 组相比，OA-L 组的胶原 2 和转化生长因子β免疫表达更高。
结论
综上所述，可以认为发光二极管光生物调节疗法对关节组织合成的细胞外基质蛋白的表达有积极影响。
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