手部功能在退行性小脑疾病中的测量：一项病例对照初步研究。
Measurements of Hand Function in Degenerative Cerebellar Disease: A Case-Control Pilot Study.
机构信息
From the Department of Physical Medicine and Rehabilitation, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York (SB); Human Motor Recovery Laboratory, Burke Neurological Institute, White Plains, New York (SM, TK); Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York (S-HK); Department of Rehabilitation and Regenerative Medicine, Columbia University College of Physicians and Surgeons, New York, New York (JS); Department of Rehabilitation Medicine, Weill Cornell Medical College, New York, New York (JS); and New York Presbyterian Hospital, New York, New York (JS).
出版信息
Am J Phys Med Rehabil. 2020 Sep;99(9):795-800. doi: 10.1097/PHM.0000000000001411.
OBJECTIVE
The aim of the study was to determine the association of Nine Hole Peg Test, Box and Block Test, Jebsen-Taylor Hand Function Test, and kinematic measures of a simple reaching task with ataxia severity in adults with degenerative cerebellar disease.
DESIGN
Fourteen adults with cerebellar degeneration were recruited, and ataxia severity was determined using the Scale for the Assessment and Rating of Ataxia. The median Scale for the Assessment and Rating of Ataxia score was used to divide participants into less and more severe ataxia groups. The two groups' average scores on the hand function tests were compared, and correlation of each test with ataxia severity was determined.
RESULTS
The Nine Hole Peg Test, Box and Block Test, and Jebsen-Taylor Hand Function Test all differentiated between less and more severe ataxia groups, and the Nine Hole Peg Test performed with the participant's dominant hand had the highest correlation with ataxia severity (rs = 0.92, P < 0.01). Although accuracy, precision, and number of submovements were statistically different between healthy individuals and the more ataxic participant group, most kinematic measures were not significantly different between the less and more severe ataxic groups.
CONCLUSION
Overall, our results indicate that all three clinical tests correlate with ataxia severity. Larger future studies should examine the reliability and validity of these hand function measures in adults with degenerative cerebellar disease.
目的
本研究旨在确定九洞钉测试、方块-积木测试、Jebsen-Taylor 手功能测试以及简单伸手任务的运动学测量与成人退行性小脑疾病患者的共济失调严重程度之间的关联。
设计
招募了 14 名患有小脑变性的成年人，并使用共济失调评定量表来确定共济失调严重程度。使用中位数共济失调评定量表评分将参与者分为共济失调较轻和较重两组。比较两组在手功能测试中的平均得分，并确定每个测试与共济失调严重程度的相关性。
结果
九洞钉测试、方块-积木测试和 Jebsen-Taylor 手功能测试均能区分共济失调较轻和较重两组，且使用参与者惯用手进行的九洞钉测试与共济失调严重程度相关性最高（rs = 0.92，P < 0.01）。尽管健康个体与共济失调较重组之间在准确性、精度和亚运动次数方面存在统计学差异，但大多数运动学测量在共济失调较轻和较重两组之间没有显著差异。
结论
总体而言，我们的结果表明所有三种临床测试均与共济失调严重程度相关。未来更大规模的研究应检验这些手部功能测量在退行性小脑疾病成人中的可靠性和有效性。
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