稳定型冠心病患者纤维蛋白原与白蛋白比值和冠状动脉疾病严重程度之间的关联。
The association between the fibrinogen-to-albumin ratio and coronary artery disease severity in patients with stable coronary artery disease.
作者信息
Celebi Savas, Ozcan Celebi Ozlem, Berkalp Berkten, Amasyali Basri
机构信息
Department of Cardiology, TOBB Economics and Technology University Medical School.
Department of Cardiology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
出版信息
Coron Artery Dis. 2020 Sep;31(6):512-517. doi: 10.1097/MCA.0000000000000868.
OBJECTIVE
Fibrinogen-to-albumin ratio (FAR) is an inexpensive and easily measurable novel inflammatory index that has been found to be associated with atherosclerosis. In this study, we aimed to investigate the association between the FAR and coronary artery disease (CAD) severity in patients with stable CAD.
METHODS
In total, 356 consecutive patients with CAD were classified into three groups, those with a low Synergy between percutaneous coronary intervention and the Taxus and Cardiac Surgery Study (SYNTAX) score (≤22), those with an intermediate SYNTAX score (23≥ SYNTAX score ≤32) and those with a high SYNTAX score (>32).
RESULTS
We determined that there were significant differences in the mean age (P < 0.001), male gender (P = 0.008), serum fibrinogen (P = 0.03), low-density lipoprotein cholesterol (P < 0.001) and FAR (P < 0.001) among the SYNTAX score groups. A strong positive correlation was detected between FAR and SYNTAX score (r = 0.899; P < 0.001), and the cutoff level of FAR for high SYNTAX score was 82 (sensitivity of 82%, specificity of 88.3% and an area under the curve of 0.826).
CONCLUSION
The novel inflammatory index, FAR, is significantly associated with the severity of CAD in patients with stable CAD.
目的
纤维蛋白原与白蛋白比值（FAR）是一种廉价且易于测量的新型炎症指标，已发现其与动脉粥样硬化有关。在本研究中，我们旨在探讨FAR与稳定型冠心病（CAD）患者冠状动脉疾病严重程度之间的关联。
方法
总共356例连续的CAD患者被分为三组，即经皮冠状动脉介入治疗与紫杉醇及心脏手术研究（SYNTAX）评分低（≤22）的患者、SYNTAX评分中等（23≥SYNTAX评分≤32）的患者和SYNTAX评分高（>32）的患者。
结果
我们确定SYNTAX评分组之间在平均年龄（P<0.001）、男性（P=0.008）、血清纤维蛋白原（P=0.03）、低密度脂蛋白胆固醇（P<0.001）和FAR（P<0.001）方面存在显著差异。FAR与SYNTAX评分之间检测到强正相关（r=0.899；P<0.001）,SYNTAX评分高时FAR的截断水平为82（敏感性为82%，特异性为88.3%，曲线下面积为0.826）。
结论
新型炎症指标FAR与稳定型CAD患者的CAD严重程度显著相关。
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