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Immunoglobulin heavy and light chain gene features are correlated with primary cold agglutinin disease onset and activity.免疫球蛋白重链和轻链基因特征与原发性冷凝集素病的发病及活动相关。
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2
Restriction in the repertoire of the immunoglobulin light chain subgroup in pathological cold agglutinins with anti-Pr specificity.具有抗-Pr特异性的病理性冷凝集素中免疫球蛋白轻链亚群库的限制。
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A murine transgenic model of human cold agglutinin disease.人类冷凝集素病的小鼠转基因模型。
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Lymphoproliferative disease with IgM lambda monoclonal protein and autoimmune hemolytic anemia. A report of four cases and a review of the literature.伴有IgM λ单克隆蛋白和自身免疫性溶血性贫血的淋巴增殖性疾病。4例报告及文献复习
Am J Med. 1978 Mar;64(3):434-40. doi: 10.1016/0002-9343(78)90229-2.
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Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. Evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype.两种IgM冷凝集素V区的核苷酸序列分析。VH4-21基因片段负责主要交叉反应独特型的证据。
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[Clinical significance of cold agglutinin titration].[冷凝集素滴定的临床意义]
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Distinct groups of autoantigens as drivers of ocular adnexal MALT lymphoma pathogenesis.不同的自身抗原群作为眼附属器黏膜相关淋巴组织淋巴瘤发病机制的驱动因素。
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Cold agglutinin-associated B-cell lymphoproliferative disease shows highly recurrent gains of chromosome 3 and 12 or 18.冷凝集素相关B细胞淋巴增殖性疾病表现出3号、12号或18号染色体高度频发的增益。
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本文引用的文献

1
Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens.人类淋巴瘤细胞的存活需要自身抗原与B细胞受体结合。
Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13447-54. doi: 10.1073/pnas.1514944112. Epub 2015 Oct 19.
2
The many faces of small B cell lymphomas with plasmacytic differentiation and the contribution of MYD88 testing.具有浆细胞分化的小B细胞淋巴瘤的多种面貌及MYD88检测的作用
Virchows Arch. 2016 Mar;468(3):259-75. doi: 10.1007/s00428-015-1858-9. Epub 2015 Oct 10.
3
Restricted, canonical, stereotyped and convergent immunoglobulin responses.受限、规范、刻板和趋同的免疫球蛋白反应。
Philos Trans R Soc Lond B Biol Sci. 2015 Sep 5;370(1676). doi: 10.1098/rstb.2014.0238.
4
Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.通过可变区糖基化和突变远离自身反应性来拯救无能 B 细胞上的自身抗体。
Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2567-75. doi: 10.1073/pnas.1406974111. Epub 2014 May 12.
5
Primary cold agglutinin-associated lymphoproliferative disease: a B-cell lymphoma of the bone marrow distinct from lymphoplasmacytic lymphoma.原发性冷凝集素相关淋巴增殖性疾病：一种与淋巴浆细胞淋巴瘤不同的骨髓B细胞淋巴瘤。
Haematologica. 2014 Mar;99(3):497-504. doi: 10.3324/haematol.2013.091702. Epub 2013 Oct 18.
6
MYD88 L265P somatic mutation in Waldenström's macroglobulinemia.瓦尔登斯特伦巨球蛋白血症中的 MYD88 L265P 体细胞突变。
N Engl J Med. 2012 Aug 30;367(9):826-33. doi: 10.1056/NEJMoa1200710.
7
IGKV3 proteins as candidate "off-the-shelf" vaccines for kappa-light chain-restricted B-cell non-Hodgkin lymphomas.IGKV3 蛋白作为 κ 轻链限制性 B 细胞非霍奇金淋巴瘤的候选“现货”疫苗。
Clin Cancer Res. 2012 Aug 1;18(15):4080-91. doi: 10.1158/1078-0432.CCR-12-0763. Epub 2012 Jun 15.
8
Evidence for involvement of a hydrophobic patch in framework region 1 of human V4-34-encoded Igs in recognition of the red blood cell I antigen.人V4-34编码的免疫球蛋白框架区1中疏水补丁参与识别红细胞I抗原的证据。
J Immunol. 2002 Oct 1;169(7):3777-82. doi: 10.4049/jimmunol.169.7.3777.
9
Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma.通过体细胞突变在免疫球蛋白可变区获得潜在的N-糖基化位点是滤泡性淋巴瘤的一个显著特征。
Blood. 2002 Apr 1;99(7):2562-8. doi: 10.1182/blood.v99.7.2562.
10
Somatic mutation hotspots correlate with DNA polymerase eta error spectrum.体细胞突变热点与DNA聚合酶η错误谱相关。
Nat Immunol. 2001 Jun;2(6):530-6. doi: 10.1038/88732.

Immunoglobulin heavy and light chain gene features are correlated with primary cold agglutinin disease onset and activity.

作者信息

Małecka Agnieszka, Trøen Gunhild, Tierens Anne, Østlie Ingunn, Małecki Jędrzej, Randen Ulla, Berentsen Sigbjørn, Tjønnfjord Geir E, Delabie Jan M A

机构信息

Department of Pathology, Oslo University Hospital, Norway

Department of Pathology, Oslo University Hospital, Norway.

出版信息

Haematologica. 2016 Sep;101(9):e361-4. doi: 10.3324/haematol.2016.146126. Epub 2016 May 19.

DOI:10.3324/haematol.2016.146126
PMID:27198717
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5060031/
Abstract
摘要