Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Germany.
Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin, Turin, Italy.
Horm Metab Res. 2020 Jun;52(6):379-385. doi: 10.1055/a-1120-8647. Epub 2020 Mar 13.
Primary aldosteronism (PA) is the most common form of endocrine hypertension. Agonistic autoantibodies against the angiotensin II type 1 receptor (ATR-Abs) have been described in transplantation medicine and women with pre-eclampsia and more recently in patients with PA. Any functional role of ATR-Abs in either of the two main subtypes of PA (aldosterone-producing adenoma or bilateral adrenal hyperplasia) requires clarification. In this review, we discuss the studies performed to date on ATR-Abs in PA.
原发性醛固酮增多症（PA）是内分泌性高血压最常见的形式。血管紧张素 II 型 1 受体（ATR）自身抗体在移植医学、子痫前期妇女中以及最近在 PA 患者中已被描述。ATR 自身抗体在 PA 的两种主要亚型（醛固酮瘤或双侧肾上腺增生）中的任何功能作用都需要澄清。在这篇综述中，我们讨论了迄今为止在 PA 中进行的关于 ATR 自身抗体的研究。
