2nd Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
MTA-SE Molecular Medicine Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary.
Horm Metab Res. 2020 Jun;52(6):394-403. doi: 10.1055/a-1116-2366. Epub 2020 Mar 13.
MicroRNAs, the endogenous mediators of RNA interference, interact with the renin-angiotensin-aldosterone system, regulate aldosterone secretion and aldosterone effects. Some novel data show that the expression of some microRNAs is altered in primary aldosteronism, and some of these appear to have pathogenic relevance, as well. Differences in the circulating microRNA expression profiles between the two major forms of primary aldosteronism, unilateral aldosterone-producing adenoma and bilateral adrenal hyperplasia have also been shown. Here, we present a brief synopsis of these findings focusing on the potential relevance of microRNA in primary aldosteronism.
微小 RNA 是 RNA 干扰的内源性介质，与肾素-血管紧张素-醛固酮系统相互作用，调节醛固酮的分泌和作用。一些新的数据表明，某些微小 RNA 的表达在原发性醛固酮增多症中发生改变，其中一些似乎也具有发病相关性。单侧醛固酮分泌腺瘤和双侧肾上腺增生这两种主要形式的原发性醛固酮增多症之间的循环微小 RNA 表达谱也存在差异。在这里，我们简要概述了这些发现，重点关注微小 RNA 在原发性醛固酮增多症中的潜在相关性。
