Anthoney Daud, Zahid Shahreen, Khalid Hina, Khurshid Zohaib, Shah Asma Tufail, Chaudhry Aqif Anwar, Khan Abdul Samad
Department of Science of Dental Materials, Postgraduate Medical Institute, Lahore, Pakistan.
Department of Dental Materials, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan.
Eur J Dent. 2020 Feb;14(1):45-54. doi: 10.1055/s-0040-1703418. Epub 2020 Mar 13.
Dentin hypersensitivity (DH) is mainly due to the loss and replenishment of minerals from tooth structure, where the lost minerals can be rehabilitated with a biomimetic approach. The objectives were to determine the relative dentin abrasivity (RDA) of experimental (EXT) dentifrices and to determine the efficacy to occlude dentinal tubules.
Experimental dentifrices contained nano-fluoridated bioactive glass (n-FBG: 1.5 wt.% [EXT-A], 2.5 wt.% [EXT-B], and 3.5 wt.% [EXT-C]), nano-zinc oxide (n-ZnO), and thymoquinone as active agents. Bovine dentin blocks were subjected to brushing treatments as per groups, that is, distilled water; commercial dentifrice (control, CT); EXT toothpastes; and EXT-D without active agents. Samples were tested for three-dimensional (3D) abrasion analysis according to ISO-11609:2010 (International Organization for Standardization [ISO]). The roughness average (Ra), RDA, surface topography, and elemental compositions were investigated.
One-way analysis of variance (ANOVA) with post-hoc Tukey's and Tamhane's test was performed for characterizations using Statistical Package for the Social Sciences (SPSS) version 21. The result was considered significant with -value ≤ 0.05.
Comparisons of Ra differed significantly between all groups with < 0.05 except CT and EXT-A. The RDA values of EXT-A, EXT-B, and EXT-C were calculated as 74.04, 84.26, and 116.24, respectively, which were well within the acceptable limit set by international standards. All n-FBG containing dentifrices demonstrated uniform occlusion of dentinal tubules; however, highly concentrated EXT dentifrices showed more occlusion.
Acceptable range of RDA and superior occlusion of tubules by novel dentifrices suggest that it may be recommended for treating DH.
牙本质过敏症（DH）主要是由于牙齿结构中矿物质的流失和补充，流失的矿物质可用仿生方法修复。目的是确定实验性（EXT）牙膏的相对牙本质磨损性（RDA），并确定其封闭牙本质小管的功效。
实验性牙膏含有纳米氟化生物活性玻璃（n-FBG：1.5重量%[EXT-A]、2.5重量%[EXT-B]和3.5重量%[EXT-C]）、纳米氧化锌（n-ZnO）和百里醌作为活性剂。将牛牙本质块按组进行刷牙处理，即蒸馏水；市售牙膏（对照，CT）；EXT牙膏；以及不含活性剂的EXT-D。根据ISO-11609:2010（国际标准化组织[ISO]）对样品进行三维（3D）磨损分析。研究了平均粗糙度（Ra）、RDA、表面形貌和元素组成。
使用社会科学统计软件包（SPSS）21版进行单因素方差分析（ANOVA）以及事后Tukey检验和Tamhane检验进行特征分析。结果以P值≤0.05为有统计学意义。
除CT组和EXT-A组外，所有组之间的Ra比较差异均有统计学意义（P<0.05）。EXT-A、EXT-B和EXT-C的RDA值分别计算为74.04、84.26和116.24，均在国际标准设定的可接受范围内。所有含n-FBG的牙膏均显示出牙本质小管的均匀封闭；然而，高浓度的EXT牙膏显示出更多的封闭。
新型牙膏的RDA可接受范围以及对小管的优异封闭表明，它可能推荐用于治疗牙本质过敏症。
