Toledano-Osorio Manuel, Osorio Raquel, Osorio Estrella, Medina-Castillo Antonio L, Toledano Manuel
Faculty of Dentistry, Colegio Máximo de Cartuja s/n, University of Granada, 18071 Granada, Spain.
Analytic Chemistry Department, Faculty of Sciences, Campus Fuentenueva s/n, University of Granada, 18071 Granada, Spain.
Nanomaterials (Basel). 2021 Nov 22;11(11):3150. doi: 10.3390/nano11113150.
Tubule occlusion and remineralization are considered the two main goals of dentin hypersensitivity treatment. The objective is to assess the ability of dentifrices containing zinc-doped polymeric nanoparticles (NPs) to enduringly occlude the dentinal tubules, reinforcing dentin's mechanical properties. Fifteen dentin surfaces were acid-treated for dentinal tubule exposure and brushed with (1) distilled water, or with experimental pastes containing (2) 1% of zinc-doped NPs, (3) 5% of zinc-doped NPs, (4) 10% of zinc-doped NPs or (5) Sensodyne. Topographical and nanomechanical analyses were performed on treated dentin surfaces and after a citric acid challenge. ANOVA and Student-Newman-Keuls tests were used ( < 0.05). The main results indicate that all pastes produced tubule occlusion (100%) and reinforced mechanical properties of intertubular dentin (complex modulus was above 75 GPa). After the citric acid challenge, only those pastes containing zinc-doped NPs were able to maintain tubular occlusion, as specimens treated with Sensodyne have around 30% of tubules opened. Mechanical properties were maintained for dentin treated with Zn-doped NPs, but in the case of specimens treated with Sensodyne, complex modulus values were reduced below 50 GPa. It may be concluded that zinc-doped NPs at the lowest tested concentration produced acid-resistant tubular occlusion and increased the mechanical properties of dentin.
牙本质小管封闭和再矿化被认为是牙本质过敏症治疗的两个主要目标。目的是评估含有锌掺杂聚合物纳米颗粒（NPs）的牙膏持久封闭牙本质小管、增强牙本质机械性能的能力。对15个牙本质表面进行酸处理以使牙本质小管暴露，并用（1）蒸馏水、或含有（2）1%锌掺杂NPs、（3）5%锌掺杂NPs、（4）10%锌掺杂NPs的实验性牙膏或（5）舒适达牙膏进行刷牙。对处理后的牙本质表面以及柠檬酸刺激后进行形貌和纳米力学分析。使用方差分析和学生-纽曼-基尔斯检验（<0.05）。主要结果表明，所有牙膏均产生了小管封闭（100%）并增强了管间牙本质的机械性能（复合模量高于75 GPa）。柠檬酸刺激后，只有那些含有锌掺杂NPs的牙膏能够维持小管封闭，因为用舒适达处理的标本约有30%的小管开放。用锌掺杂NPs处理的牙本质的机械性能得以维持，但在用舒适达处理的标本中，复合模量值降至50 GPa以下。可以得出结论，在测试的最低浓度下，锌掺杂NPs产生了耐酸小管封闭并提高了牙本质的机械性能。
