School of Public Health, Xinxiang Medical University, Xinxiang 453003, Henan, China.
School of Management, Xinxiang Medical University, Xinxiang 453003, Henan, China.
Int J Environ Res Public Health. 2020 Mar 11;17(6):1818. doi: 10.3390/ijerph17061818.
Metabolic associated fatty liver disease (MAFLD) is recognized as the liver disease component of metabolic syndrome, which is mainly related to insulin resistance and genetic susceptibility. It is the most prevalent chronic liver disease worldwide. With rapid lifestyle transitions, its prevalence worldwide is increasing, and tremendous challenges in controlling this pandemic are arising. The objective of this study was to investigate the prevalence and risk factors of MAFLD in rural areas of Xinxiang, Henan in 2017. We conducted a cross-sectional analysis of rural inhabitants aged 20-79 years in Xinxiang, Henan in 2017, using cluster random sampling ( = 9140). Physical examinations were conducted at local clinics from April to June 2017. After overnight fasting, all participants underwent physical examinations, blood routine tests, biochemical examinations, and liver ultrasound and completed questionnaires. We investigated the crude and age-adjusted MAFLD prevalence and analyzed the characteristics of those with, and without, MAFLD, using logistic regression. Approximately 2868 (31.38%) participants were diagnosed with MAFLD. The overall age-adjusted MAFLD prevalence was 29.85% (men: 35.36%; women: 26.49%). The MAFLD prevalence increased with age, and peaked at the 50-59-year age group, and then began to decline. Higher body mass index, waist circumference, percentage of lymphocytes, levels of hemoglobin, platelet count, triglyceride, fasting plasma glucose, and serum uric acid were independently and positively correlated with MAFLD; In contrary, active physical activity and high-density lipoprotein cholesterol were negatively correlated with MAFLD. In summary, the MAFLD prevalence in the study population was 29.85%. Higher body mass index, waist circumference, percentage of lymphocytes, levels of hemoglobin, platelet count, triglyceride, fasting plasma glucose, and serum uric acid were risk factors for MAFLD.
代谢相关性脂肪性肝病（MAFLD）被认为是代谢综合征的肝脏疾病组分，主要与胰岛素抵抗和遗传易感性相关。它是全球最普遍的慢性肝脏疾病。随着生活方式的快速转变，其在全球的患病率正在增加，控制这一流行疾病的巨大挑战正在出现。本研究旨在调查 2017 年河南新乡农村地区 MAFLD 的患病率及其危险因素。我们采用整群随机抽样方法（=9140），对 2017 年河南新乡年龄在 20-79 岁的农村居民进行了横断面分析。2017 年 4 月至 6 月在当地诊所进行体格检查。所有参与者均空腹过夜后进行体格检查、血常规检查、生化检查、肝脏超声检查，并完成问卷调查。我们调查了 MAFLD 的粗患病率和年龄调整后患病率，并使用逻辑回归分析了 MAFLD 患者和非 MAFLD 患者的特征。约 2868（31.38%）名参与者被诊断为 MAFLD。总体年龄调整后 MAFLD 的患病率为 29.85%（男性：35.36%；女性：26.49%）。MAFLD 的患病率随年龄增长而增加，在 50-59 岁年龄组达到峰值，然后开始下降。较高的体质指数、腰围、淋巴细胞百分比、血红蛋白、血小板计数、三酰甘油、空腹血糖和血清尿酸水平与 MAFLD 独立正相关；相反，积极的体育活动和高密度脂蛋白胆固醇与 MAFLD 呈负相关。总之，研究人群中 MAFLD 的患病率为 29.85%。较高的体质指数、腰围、淋巴细胞百分比、血红蛋白、血小板计数、三酰甘油、空腹血糖和血清尿酸水平是 MAFLD 的危险因素。
