Ren Shutong, Chen Siyu, Huang Jingru, Yu Rong, Wu Yunli, Peng Xian-E
Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, 350122, People's Republic of China.
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen, 361104, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 Sep 7;17:3343-3354. doi: 10.2147/DMSO.S476045. eCollection 2024.
This study aimed to explore the association between serum uric acid (sUA) levels and metabolic-associated fatty liver disease (MAFLD) in Southeast China.
We performed a cross-sectional study of 2605 subjects who underwent physical examination between 2015 and 2017 in Southeast China. To explore the association between sUA levels and the risk of MAFLD, we employed logistic regression, restricted cubic spline (RCS), subgroups and multiplicative interaction analysis.
Logistic regression analysis showed a positive association between sUA and MAFLD [ (95% )= 1.90 (1.49 ~ 2.42)], [ (95% )= 2.01 (1.54 ~ 2.62)], [ (95% = 1.15 (0.62 ~ 2.11)], respectively. The RCS plot presented a significant nonlinear dose-response relationship between sUA levels and MAFLD risk, and the risk of MAFLD increased significantly when sUA> 5.56 mg/dL ( < 0.001). Subgroups analysis revealed that the positive association between sUA and MAFLD was consistent across strata of gender, age, BMI, drinking status, smoking status and tea drinking status. Significant associations between sUA and MAFLD were not only found in males but also existed in subjects whose age ≤60, BMI ≥24 kg/m, drinkers, smokers and tea-drinkers. Adjusted s were estimated to be 2.01, 1.95, 2.11, 2.29, 2.64 and 2.20, respectively. Multiplicative interactions were not observed between gender, age, drinking status, smoking status, tea drinking status and sUA (all > 0.05).
According to our study, sUA was positively associated with the risk of MAFLD. Additionally, the risk of MAFLD increased significantly when sUA levels exceeded 5.56 mg/dL. Our study may help clarify whether sUA plays a diagnostic role in MAFLD.
本研究旨在探讨中国东南部地区血清尿酸（sUA）水平与代谢相关脂肪性肝病（MAFLD）之间的关联。
我们对2015年至2017年在中国东南部地区接受体检的2605名受试者进行了横断面研究。为了探究sUA水平与MAFLD风险之间的关联，我们采用了逻辑回归、受限立方样条（RCS）、亚组分析和乘法交互作用分析。
逻辑回归分析显示sUA与MAFLD之间存在正相关关系[比值比（95%置信区间）=1.90（1.492.42）]，[比值比（95%置信区间）=2.01（1.542.62）]，[比值比（95%置信区间）=1.15（0.62~2.11）]。RCS图显示sUA水平与MAFLD风险之间存在显著的非线性剂量反应关系，当sUA>5.56mg/dL时，MAFLD风险显著增加（P<0.001）。亚组分析显示，sUA与MAFLD之间的正相关关系在性别、年龄、体重指数、饮酒状况、吸烟状况和饮茶状况等各层中均一致。sUA与MAFLD之间的显著关联不仅在男性中发现，在年龄≤60岁、体重指数≥24kg/m²、饮酒者、吸烟者和饮茶者中也存在。调整后的比值比估计分别为2.01、1.95、2.11、2.29、2.64和2.20。在性别、年龄、饮酒状况、吸烟状况、饮茶状况和sUA之间未观察到乘法交互作用（所有P>0.05）。
根据我们的研究，sUA与MAFLD风险呈正相关。此外，当sUA水平超过5.56mg/dL时，MAFLD风险显著增加。我们的研究可能有助于阐明sUA在MAFLD中是否起诊断作用。
