Xiao Shao-Jun, Fu Guang-Jian, Lv Ya-Lan, Zhong Xiao-Ni, Wang Run-Hua
Department of Medical Statistics, School of Public Health, Chongqing, China.
J Gastroenterol Hepatol. 2014 Feb;29(2):358-64. doi: 10.1111/jgh.12334.
Fatty liver disease has become common hepatic disease not only in western countries but also in developing countries in Asia-Pacific area. Our aim was to determine the prevalence and risk factors of fatty liver disease as well as its correlation with metabolic syndrome in young and middle-aged population.
Data were collected from check-up center at the 1st Affiliated Hospital of Chongqing Medical University in 2011. Relationships of fatty liver disease and age, body mass index, and metabolic syndrome were determined. Logistic regression was performed to identify the risk factors for fatty liver disease.
Data of 18 676 subjects (mean age 40.55 ± 9.94 ranging from 18 to 59) were analyzed. The prevalence of fatty liver disease was 22.0% and increased along with age, body mass index, and the presence and severity of metabolic syndrome. In logistic regression, living area was significantly associated with fatty liver in total population. Male, overweight and obese, waist-to-height ratio ≥ 0.5, hypertension, hypercholesterolemia, high triglyceride, low high-density lipoprotein cholesterol, and fasting plasma glucose ≥ 7.0 mmol/L were common independent risk factors for fatty liver disease in urban and rural areas. Older age and white blood cell over 5.5 ×10(9) /L were related to fatty liver disease in urban area. Obesity was the most important factors in both areas.
Fatty liver disease was prevalent in young and middle-aged population and mainly associated to multiple metabolic disorders.
脂肪性肝病不仅在西方国家，而且在亚太地区的发展中国家都已成为常见的肝脏疾病。我们的目的是确定中青年人群中脂肪性肝病的患病率、危险因素及其与代谢综合征的相关性。
收集2011年重庆医科大学附属第一医院体检中心的数据。确定脂肪性肝病与年龄、体重指数和代谢综合征之间的关系。进行逻辑回归分析以确定脂肪性肝病的危险因素。
分析了18676名受试者（平均年龄40.55±9.94岁，年龄范围为18至59岁）的数据。脂肪性肝病的患病率为22.0%，并随着年龄、体重指数以及代谢综合征的存在和严重程度而增加。在逻辑回归分析中，居住地区与总人群的脂肪性肝病显著相关。男性、超重和肥胖、腰高比≥0.5、高血压、高胆固醇血症、高甘油三酯、低高密度脂蛋白胆固醇以及空腹血糖≥7.0 mmol/L是城乡地区脂肪性肝病常见的独立危险因素。年龄较大和白细胞超过5.5×10⁹/L与城市地区的脂肪性肝病有关。肥胖是两个地区最重要的因素。
脂肪性肝病在中青年人群中普遍存在，主要与多种代谢紊乱有关。
