Department of Neurology, King Edward Medical University / Mayo Hospital, Lahore, Pakistan.
Department of Rheumatology, Shaikh Zayed Postgraduate Medical Institute, Lahore, Pakistan.
J Coll Physicians Surg Pak. 2020 Mar;30(3):321-323. doi: 10.29271/jcpsp.2020.03.321.
Aquaporin-4 antibodies are hallmark of neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorders (NMOSD) that are distinct disease entities. We report a 24-year male with NMO, who presented with Brown-Sequard syndrome. Clinical and laboratory parameters confirmed the diagnosis of systemic lupus erythematosus (SLE). Involvement of sympathetic trunk causing Horner's syndrome and a wide time lapse of 13 years from the occurrence of optic neuritis to myelitis with no relapses in between is a rarity to be seen in NMO associated with SLE.
水通道蛋白 4 抗体是视神经脊髓炎（NMO）和视神经脊髓炎谱系疾病（NMOSD）的标志性抗体，这两种疾病是截然不同的实体疾病。我们报告了一例 24 岁的男性 NMO 患者，他表现为 Brown-Sequard 综合征。临床和实验室参数证实了系统性红斑狼疮（SLE）的诊断。交感干受累导致霍纳综合征，视神经炎和脊髓炎之间的时间间隔长达 13 年，且无复发，这在与 SLE 相关的 NMO 中很少见。
