• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

核孔蛋白凝聚物驱动卵母细胞中的核孔复合物组装。

Nucleoporin Condensates Drive Nuclear Pore Complex Assembly in Oocytes.

机构信息

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.

出版信息

Trends Biochem Sci. 2020 Apr;45(4):278-280. doi: 10.1016/j.tibs.2020.01.009. Epub 2020 Feb 13.

DOI:10.1016/j.tibs.2020.01.009
PMID:32169173
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7505689/
Abstract

Oocytes stockpile nuclear pore complexes (NPCs) in cytoplasmic membrane sheets called annulate lamellae (AL) in preparation for rapid cell cycles during embryogenesis. Recently, Hampoelz et al. reported that AL-NPC assembly depends on the coordinated formation, transport, and interaction of biomolecular condensates containing distinct sets of nucleoporins.

摘要

卵母细胞在细胞质膜片中储备核孔复合物（NPC），这种细胞质膜片被称为环状片层（AL），以备胚胎发生过程中快速的细胞周期。最近，Hampoelz 等人报告称，AL-NPC 的组装取决于包含不同核孔蛋白的生物分子凝聚体的协调形成、运输和相互作用。

相似文献

1
Nucleoporin Condensates Drive Nuclear Pore Complex Assembly in Oocytes.核孔蛋白凝聚物驱动卵母细胞中的核孔复合物组装。
Trends Biochem Sci. 2020 Apr;45(4):278-280. doi: 10.1016/j.tibs.2020.01.009. Epub 2020 Feb 13.
2
Nuclear Pores Assemble from Nucleoporin Condensates During Oogenesis.核孔在卵子发生过程中从核孔蛋白凝聚体中组装形成。
Cell. 2019 Oct 17;179(3):671-686.e17. doi: 10.1016/j.cell.2019.09.022.
3
Nuclear pore complex assembly studied with a biochemical assay for annulate lamellae formation.通过用于环状片层形成的生化分析研究核孔复合体组装。
J Cell Biol. 1995 Jun;129(6):1459-72. doi: 10.1083/jcb.129.6.1459.
4
[Assembly and Disassembly of the Nuclear Pore Complex: A View from the Structural Side].[核孔复合体的组装与拆卸：结构视角]
Mol Biol (Mosk). 2023 Jul-Aug;57(4):573-586.
5
Postmitotic annulate lamellae assembly contributes to nuclear envelope reconstitution in daughter cells.有丝分裂后环层板的组装有助于子细胞中核膜的重建。
J Biol Chem. 2019 Jul 5;294(27):10383-10391. doi: 10.1074/jbc.AC119.008171. Epub 2019 May 31.
6
Abnormal assembly of annulate lamellae and nuclear pore complexes coincides with fertilization arrest at the pronuclear stage of human zygotic development.环状片层和核孔复合体的异常组装与人类合子发育原核阶段的受精停滞同时出现。
Hum Reprod. 2003 Mar;18(3):576-82. doi: 10.1093/humrep/deg114.
7
Annulate lamellae play only a minor role in the storage of excess nucleoporins in Drosophila embryos.环状片层在果蝇胚胎中多余核孔蛋白的储存方面仅起次要作用。
Traffic. 2004 Mar;5(3):152-64. doi: 10.1111/j.1600-0854.2004.0166.x.
8
RanGTP mediates nuclear pore complex assembly.RanGTP介导核孔复合体组装。
Nature. 2003 Aug 7;424(6949):689-94. doi: 10.1038/nature01898. Epub 2003 Jul 30.
9
Assembly of nuclear pore complexes and annulate lamellae promotes normal pronuclear development in fertilized mammalian oocytes.核孔复合体和环孔片层的组装促进受精哺乳动物卵母细胞中正常原核发育。
J Cell Sci. 1998 Oct;111 ( Pt 19):2841-54. doi: 10.1242/jcs.111.19.2841.
10
Preassembly of annulate lamellae in egg extracts inhibits nuclear pore complex formation, but not nuclear membrane assembly.卵提取物中环孔片层的预组装会抑制核孔复合体的形成，但不会抑制核膜组装。
Eur J Cell Biol. 1997 Jul;73(3):259-69.

引用本文的文献

1
Formation of nuclear CPSF6/CPSF5 biomolecular condensates upon HIV-1 entry into the nucleus is important for productive infection.核 CPSF6/CPSF5 生物分子凝聚物的形成对于 HIV-1 进入细胞核后的有效感染很重要。
Sci Rep. 2023 Jul 6;13(1):10974. doi: 10.1038/s41598-023-37364-x.
2
Insight into membraneless organelles and their associated proteins: Drivers, Clients and Regulators.对无膜细胞器及其相关蛋白的深入了解：驱动因素、作用对象和调节因子
Comput Struct Biotechnol J. 2021 Jun 29;19:3964-3977. doi: 10.1016/j.csbj.2021.06.042. eCollection 2021.

本文引用的文献

1
Nuclear Pores Assemble from Nucleoporin Condensates During Oogenesis.核孔在卵子发生过程中从核孔蛋白凝聚体中组装形成。
Cell. 2019 Oct 17;179(3):671-686.e17. doi: 10.1016/j.cell.2019.09.022.
2
The Structure of the Nuclear Pore Complex (An Update).核孔复合体的结构（更新）。
Annu Rev Biochem. 2019 Jun 20;88:725-783. doi: 10.1146/annurev-biochem-062917-011901. Epub 2019 Mar 18.
3
Nuclear pore assembly proceeds by an inside-out extrusion of the nuclear envelope.核孔复合体的组装是通过核膜由内向外挤出的方式进行的。
Elife. 2016 Sep 15;5:e19071. doi: 10.7554/eLife.19071.
4
Pre-assembled Nuclear Pores Insert into the Nuclear Envelope during Early Development.预组装的核孔在早期发育过程中插入核膜。
Cell. 2016 Jul 28;166(3):664-678. doi: 10.1016/j.cell.2016.06.015. Epub 2016 Jul 7.
5
Architecture of the symmetric core of the nuclear pore.核孔对称核心的结构
Science. 2016 Apr 15;352(6283):aaf1015. doi: 10.1126/science.aaf1015. Epub 2016 Apr 14.
6
Nup153 Recruits the Nup107-160 Complex to the Inner Nuclear Membrane for Interphasic Nuclear Pore Complex Assembly.核孔复合体组装的间期核内孔膜复合物 Nup107-160 的募集需要 Nup153。
Dev Cell. 2015 Jun 22;33(6):717-28. doi: 10.1016/j.devcel.2015.04.027. Epub 2015 Jun 4.
7
Systematic kinetic analysis of mitotic dis- and reassembly of the nuclear pore in living cells.活细胞中核孔有丝分裂解体与重新组装的系统动力学分析。
J Cell Biol. 2008 Mar 10;180(5):857-65. doi: 10.1083/jcb.200707026. Epub 2008 Mar 3.
8
MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly.MEL-28/ELYS是核孔蛋白募集到染色质以及有丝分裂后核孔复合体组装所必需的。
EMBO Rep. 2007 Feb;8(2):165-72. doi: 10.1038/sj.embor.7400889. Epub 2007 Jan 19.
9
RanGTP mediates nuclear pore complex assembly.RanGTP介导核孔复合体组装。
Nature. 2003 Aug 7;424(6949):689-94. doi: 10.1038/nature01898. Epub 2003 Jul 30.
10
Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains.输入蛋白作为核输入受体和暴露碱性结构域的细胞质伴侣发挥双重功能。
EMBO J. 2002 Feb 1;21(3):377-86. doi: 10.1093/emboj/21.3.377.