University of Bremen, Centre for Biomolecular Interactions Bremen, Bremen, Germany.
University of Bremen, Centre for Biomolecular Interactions Bremen, Bremen, Germany.
Trends Biochem Sci. 2020 Apr;45(4):280-283. doi: 10.1016/j.tibs.2020.01.005. Epub 2020 Feb 15.
Signaling modules that integrate the diverse extra- and intracellular inputs to the Hippo pathway were previously unknown. By biochemical and molecular interrogation, Chen et al. established a molecular framework, the RhoA-RHPN-NF2/Kibra-STRIPAK axis, that regulates the status of Hippo core kinases and connects upstream signals to initiate and orchestrate the Hippo pathway.
信号模块将 Hippo 通路的各种细胞内外输入整合在一起，此前尚不清楚。通过生化和分子研究，Chen 等人建立了一个分子框架，即 RhoA-RHPN-NF2/Kibra-STRIPAK 轴，它调节 Hippo 核心激酶的状态，并将上游信号连接起来，启动和协调 Hippo 通路。
