miR-223 和 IL-35 之间的相关性及其在过敏性鼻炎患儿中的调节作用。
Correlation between miR-223 and IL-35 and their regulatory effect in children with allergic rhinitis.
机构信息
E.N.T. Department, the Second People's Hospital, Qilin West Road, Qujing 655000, Yunnan, China.
E.N.T. Department, the Second People's Hospital, Qilin West Road, Qujing 655000, Yunnan, China.
出版信息
Clin Immunol. 2020 May;214:108383. doi: 10.1016/j.clim.2020.108383. Epub 2020 Mar 10.
The relationship between microRNA (miR) and immune activity in allergic rhinitis (AR) remains unclear. 37 children with AR and 30 healthy children were enrolled to study the correlation of miR-223 and IL-35. There was a significant inverse correlation between plasma levels of IL-35 and serum eosinophil cationic protein (ECP) levels and eosinophils counts, while there was a positive correlation between serum miR-223 level and ECP levels and eosinophils counts. Besides, the serum levels of IL-35 or miR-223 were found to be negatively or positively correlated with TNSS respectively. The serum level of miR-223 was increased, while IL-35 level was decreased. Moreover, the expression of miRNA-223 was inversely correlated with expression of IL-35. Finally, the levels of miR-223 and IL-35 were related to Th1/Th2 cytokines, eosinophils count as well as the clinical severity. Our study suggests the potential of miR-223 and IL-35 as a molecular target for the treatment of AR.
miR 与变应性鼻炎（AR）免疫活性之间的关系尚不清楚。本研究纳入 37 例 AR 患儿和 30 例健康儿童，研究 miR-223 与 IL-35 的相关性。结果发现，血浆 IL-35 水平与血清嗜酸性粒细胞阳离子蛋白（ECP）水平和嗜酸性粒细胞计数呈显著负相关，而血清 miR-223 水平与 ECP 水平和嗜酸性粒细胞计数呈正相关。此外，IL-35 或 miR-223 的血清水平与 TNSS 分别呈负相关或正相关。miR-223 水平升高，IL-35 水平降低。此外，miRNA-223 的表达与 IL-35 的表达呈负相关。最后，miR-223 和 IL-35 的水平与 Th1/Th2 细胞因子、嗜酸性粒细胞计数以及临床严重程度有关。本研究提示 miR-223 和 IL-35 可能成为 AR 治疗的分子靶点。
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