Faculty of Medicine, American University of Beirut Medical Center Beirut, Beirut, Lebanon.
Liver Transplantation and Hepatopancreaticobiliary Surgery, Department of General Surgery, American University of Beirut Medical Center Beirut, Beirut, Lebanon.
Clin Res Hepatol Gastroenterol. 2020 Oct;44(5):733-738. doi: 10.1016/j.clinre.2020.01.001. Epub 2020 Mar 11.
BACKGROUND & AIMS: Liver fibrosis is a metabolic disease associated with several factors, mainly age, gender, immune suppression, viral hepatitis, alcohol and metabolic diseases. Here, we are assessing the gender impact on liver status in NAFLD patients younger than 50 years.
All males younger than 50 years and premenopausal females diagnosed with NAFLD were included in this study. Fibroscan results, demographics and clinical data were collected and analyzed by SPSS software. Patients were stratified based on fibrosis scores as mild or no fibrosis for F0-F1-F2 and severe fibrosis for F3 and F4. Data was analyzed and compared based on gender.
A total of 221 patients 134 males and 80 premenopausal females were included. Factors that affected liver fibrosis scores were different between males and females, where only body-mass index (BMI), white blood cells (WBC) count, and glucose level were associated with severe liver fibrosis in females. Also, liver fibrosis scores were associated with severe liver fibrosis in males only, no difference in these scores was observed in premenopausal females with severe or mild liver fibrosis.
Gender differences are prominent in NAFLD and different factors are associated with liver status in males as compared to females. Besides, fibrosis score could predict liver status in males but not in females. Further larger-scale studies are necessary to verify gender impact on liver fibrosis development.
肝纤维化是一种与多种因素相关的代谢性疾病，主要包括年龄、性别、免疫抑制、病毒性肝炎、酒精和代谢性疾病。在此，我们评估了年龄<50 岁的非酒精性脂肪性肝病（NAFLD）患者中性别对肝脏状况的影响。
本研究纳入了所有年龄<50 岁且被诊断为 NAFLD 的男性和绝经前女性患者。通过 SPSS 软件收集并分析了肝纤维化评分、人口统计学和临床数据。根据纤维化评分将患者分为轻度或无纤维化（F0-F1-F2）和严重纤维化（F3 和 F4）。基于性别对数据进行分析和比较。
共纳入 221 例患者，其中 134 例为男性，80 例为绝经前女性。影响肝纤维化评分的因素在男性和女性之间存在差异，仅体质指数（BMI）、白细胞（WBC）计数和血糖水平与女性的严重肝纤维化相关。此外，肝纤维化评分仅与男性的严重肝纤维化相关，在患有严重或轻度肝纤维化的绝经前女性中，这些评分无差异。
NAFLD 中存在明显的性别差异，与男性相比，不同因素与女性的肝脏状况相关。此外，纤维化评分可预测男性的肝脏状况，但不能预测女性的肝脏状况。需要进一步开展更大规模的研究来验证性别对肝纤维化发展的影响。
