Nantong University, Nantong, China.
Department of Neurology, Affiliated Hospital of Nantong University, Nantong, China.
Neurochem Res. 2020 May;45(5):965-971. doi: 10.1007/s11064-020-02981-9. Epub 2020 Mar 13.
With the deepening of research on epilepsy in recent decades, great progress has been made in the diagnosis and treatment of the disease. However, the clinical outcome remains unsatisfactory due to the confounding symptoms and complications, as well as complex intrinsic pathogenesis. A better understanding of the pathogenesis of epilepsy should be able to hinder the progress of the disease and improve the therapeutic effectiveness. Since the discovery of pannexin (Panx), unremitting efforts on the study of this gap junction protein family member have revealed its role in participating in the expression of various physiopathological processes. Among them, the activation or inhibition of Panx channel has been shown to regulate the release of adenosine triphosphate (ATP) and other signals, which is very important for the onset and control of nervous system diseases including epilepsy. In this article, we summarize the factors influencing the regulation of Panx channel opening, hoping to find a way to interfere with the activation or inhibition of Panx channel that regulates the signal transduction of ATP and other factors so as to control the progression of epilepsy and improve the quality of life of epileptic patients who fail to respond to the existing medical therapies and those at risk of surgical treatment.
近几十年来，随着对癫痫的研究不断深入，在癫痫的诊断和治疗方面取得了巨大进展。然而，由于症状和并发症复杂以及内在发病机制复杂，临床结果仍不尽如人意。更好地了解癫痫的发病机制应该能够阻止疾病的进展并提高治疗效果。自发现连接蛋白（Panx）以来，对这种间隙连接蛋白家族成员的不懈研究揭示了其参与各种生理病理过程表达的作用。其中，Panx 通道的激活或抑制已被证明可以调节三磷酸腺苷（ATP）和其他信号的释放，这对于包括癫痫在内的神经系统疾病的发作和控制非常重要。本文总结了影响 Panx 通道开放调节的因素，希望找到一种干预调节 ATP 和其他因素信号转导的 Panx 通道激活或抑制的方法，从而控制癫痫的进展，提高对现有医学治疗无反应和有手术治疗风险的癫痫患者的生活质量。
