Department of Veterinary Science, Maxwell H. Gluck Equine Research Center, University of Kentucky, Lexington, KY, USA.
Methods Mol Biol. 2020;2123:355-360. doi: 10.1007/978-1-0716-0346-8_26.
Equine influenza virus (EIV) is a common respiratory pathogen of horses and other equids in most parts of the world. EIV are Type A influenza viruses and two subtypes are known: H3N8 and H7N7. Both are believed to have evolved from avian influenza virus ancestors. The H3N8 subtype circulates widely, but the H7N7 subtype is thought to be extinct. The clinical disease in horses, caused by either subtype, is an upper respiratory infection of varying severity depending upon the immune status of the individual animal. It is not normally life-threatening in itself except in very young foals; however it predisposes infected equids to secondary infections capable of producing life-threatening pneumonias. Vaccines are available and widely used in some horse populations, but their effectiveness is limited by antigenic drift and other factors, and vaccinated animals with subclinical infections have been responsible for introduction of EIV into susceptible populations. EIV has spread into canines.
马流感病毒(EIV)是世界上大多数地区马和其他马科动物的常见呼吸道病原体。EIV 是 A 型流感病毒,已知有两种亚型:H3N8 和 H7N7。这两种亚型都被认为是从禽流感病毒祖先中进化而来的。H3N8 亚型广泛传播,但 H7N7 亚型已被认为灭绝。由任一亚型引起的马的临床疾病是一种上呼吸道感染,其严重程度取决于个体动物的免疫状态。除了在非常年幼的幼驹中,它本身通常不会危及生命;然而,它使受感染的马科动物易患能够产生危及生命的肺炎的继发感染。疫苗是可用的,并在一些马群中广泛使用,但它们的有效性受到抗原漂移和其他因素的限制,并且有亚临床感染的接种动物已将 EIV 传播到易感人群中。EIV 已传播到犬科动物。