小野寺预后营养指数（OPNI）是否为小细胞肺癌（SCLC）的一个预后因素？
Is Onodera's prognostic nutritional index (OPNI) a prognostic factor in small cell lung cancer (SCLC)?
作者信息
Yenibertiz Derya, Ozyurek Berna Akinci, Erdogan Yurdanur
机构信息
Department of Chest Disease, University of Health Sciences Ankara Atatürk Chest Diseases and Chest Surgery Training and Research Hospital, Ankara, Turkey.
出版信息
Clin Respir J. 2020 Aug;14(8):689-694. doi: 10.1111/crj.13185. Epub 2020 Mar 31.
INTRODUCTION
We aimed to evaluate the prognostic value of Onodera's prognostic nutritional index (OPNI) in patients with Small-cell lung cancer (SCLC).
MATERIALS AND METHODS
This study retrospectively examined 109 patients diagnosed with SCLC between January 2008 and October 2018 in our hospital. Patients were divided into two groups according to the median of OPNI values.
RESULTS
A significant difference was observed between the groups in terms of neutrophil percentage, lymphocyte count, lymphocyte percentage, C-reactive protein (CRP), albumin, lactat dehidrogenase (LDH) and neutrophil to lymphocyte ratio (NLR) (P < 0.05). LDH, CRP, neutrophil percentage and NLR (P = 0.008, P < 0.001, P = 0.001, P < 0.001, respectively) were significantly higher and albumin, lymphocyte count and lymphocyte percentage (P < 0.001, P < 0.001, P = 0.001, respectively) were significantly lower in the low OPNI group. Survival analyses have shown that mortality rates and lifespan are similar in the two groups.
CONCLUSION
The OPNI may be a helpful tool for determining the prognosis in SCLC.
引言
我们旨在评估小野寺预后营养指数（OPNI）在小细胞肺癌（SCLC）患者中的预后价值。
材料与方法
本研究回顾性分析了2008年1月至2018年10月在我院诊断为SCLC的109例患者。根据OPNI值的中位数将患者分为两组。
结果
两组在中性粒细胞百分比、淋巴细胞计数、淋巴细胞百分比、C反应蛋白（CRP）、白蛋白、乳酸脱氢酶（LDH）和中性粒细胞与淋巴细胞比值（NLR）方面存在显著差异（P<0.05）。低OPNI组的LDH、CRP、中性粒细胞百分比和NLR（分别为P = 0.008、P < 0.001、P = 0.001、P < 0.001）显著更高，而白蛋白、淋巴细胞计数和淋巴细胞百分比（分别为P < 0.001、P < 0.001、P = 0.001）显著更低。生存分析表明，两组的死亡率和寿命相似。
结论
OPNI可能是确定SCLC预后的有用工具。
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