氯氮卓：一种新的苯二氮䓬类药物，通过血液浓度确认其中毒。
Clonazolam a new designer benzodiazepine intoxication confirmed by blood concentration.
机构信息
Department of Toxicology, Poznan University of Medical Sciences, Poznan, Poland.
Department of Emergency Medicine, Poznan University of Medical Sciences, Poznan, Poland; Department of Toxicology, Raszeja Hospital, Poznan, Poland.
出版信息
Forensic Sci Int. 2020 May;310:110237. doi: 10.1016/j.forsciint.2020.110237. Epub 2020 Mar 6.
BACKGROUND
Recently the number of new psychoactive substances have significantly increased, becoming popular among experienced users of designer drugs. A significant group includes benzodiazepine derivatives, which have not been introduced as medications but are abused by people experimenting with new and classical psychoactive substances.
CASE PRESENTATION
The aim of this paper was to present the case of a clonazolam ingestion by a person who was not habituated to benzodiazepines. The intake caused only prolonged coma, decreased muscle tone, and deep tendon reflexes without any other concomitant toxicity and cardio-respiratory failure.
CONCLUSIONS
Clonazolam concentrations in patient's blood, measured three times were 0.077 mg/L, 0.015 mg/L, 0.009 mg/L after 4, 8 and 12 h, respectively. Clonazolam's human toxicity has not been well established, so any case of poisoning should be closely monitored.
背景
最近新精神活性物质的数量显著增加，在有经验的设计师药物使用者中很受欢迎。其中一个重要的群体包括苯二氮䓬类衍生物，它们尚未被作为药物引入，但被尝试新的和经典精神活性物质的人滥用。
病例介绍
本文的目的是介绍一个非苯二氮䓬类药物成瘾者摄入氯硝西泮的病例。摄入仅导致长时间昏迷、肌肉张力降低和深腱反射，没有任何其他伴随毒性和心肺衰竭。
结论
在 4、8 和 12 小时后，患者血液中的氯硝西泮浓度分别为 0.077mg/L、0.015mg/L 和 0.009mg/L。氯硝西泮的人体毒性尚未得到充分证实，因此任何中毒病例都应密切监测。
Zotero 插件