Department of Pharmacy, Southwest Hospital, Army Medical University, Chongqing, China (mainland).
Department of Pharmacy, Children's Hospital of Chongqing Medical University, Chongqing, China (mainland).
Med Sci Monit. 2020 Mar 15;26:e919435. doi: 10.12659/MSM.919435.
BACKGROUND Since the epidemiological profile of drug-induced liver injury (DILI) in China, especially the western of China, it has rarely been studied. The aim of this study was to analyze the characteristics of DILI patients in a large tertiary teaching hospital at Chongqing, a municipality in western China. MATERIAL AND METHODS The medical records of hospitalized patients which diagnosed with DILI between January 2011 and December 2016 were searched retrospectively, and demographic, clinical data, and laboratory data were retrieved for analysis. RESULTS A total of 1811 patients had been diagnosed with DILI, accounting for 0.248% of the total admissions during the same period. Among the 1096 patients included in our analysis, DILI was caused by "medications" in 462 cases (42.15%), "herbs" in 391 cases (35.68%), and combined medications in 189 cases (17.24%). The profiles for each etiology were distinctive for age, sex, clinical features, laboratory features, and types and severity of DILI. CONCLUSIONS Our study provides a systematic etiological profile of DILI in Chinese patients, which can represent references for prevention, diagnosis and treatment, supporting and promoting efforts to ease the burden of this liver disease in China.
中国，尤其是西部地区，关于药物性肝损伤（DILI）的流行病学特征鲜有研究。本研究旨在分析中国西部直辖市重庆某大型三级教学医院 DILI 患者的特征。
回顾性检索 2011 年 1 月至 2016 年 12 月期间住院诊断为 DILI 的患者病历，提取人口统计学、临床和实验室数据进行分析。
共诊断 1811 例 DILI 患者，占同期住院患者的 0.248%。在纳入的 1096 例患者中，462 例（42.15%）由“药物”引起，391 例（35.68%）由“草药”引起，189 例（17.24%）由联合用药引起。每种病因的特征在年龄、性别、临床特征、实验室特征以及 DILI 的类型和严重程度方面均有所不同。
本研究为中国患者的 DILI 病因提供了系统的病因谱，可为预防、诊断和治疗提供参考，支持并促进减轻中国此类肝脏疾病负担的努力。
