Shalash Ali, Hamid Eman, Elrassas Hanan, Abushouk Abdelrahman Ibrahim, Salem Haitham Hamdy
Department of Neurology, Faculty of Medicine, Ain Shams University, Abbasia Square, Cairo, 11517, Egypt.
Okasha Institute of Psychiatry- Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Neurol Sci. 2020 Aug;41(8):2201-2206. doi: 10.1007/s10072-020-04328-2. Epub 2020 Mar 14.
Sexual dysfunction (SD) is a common, yet under-reported, non-motor symptom (NMS) of Parkinson's disease (PD). The present study investigated the sexual functions in PD male patients, its correlation with motor and other NMSs, and their impact on health-related quality of life (HRQoL).
The sexual functions of 40 PD male patients were assessed using the International Index of Erectile Function (IIEF) and compared to 25 healthy age-matched controls. Patients were evaluated using the NMS Scale (NMSS) and the Arabic version of the Parkinson's-Disease Questionnaire (PDQ-39). We compared the sexual functions of younger (≤ 55 years) and elder (> 55 years) males and tested the correlations between sexual functions and motor, other NMSs, and HRQoL.
Seventy percent of PD male patients reported erectile dysfunction. They showed significantly worse total (p < 0.001) and subscores of IIEF, compared to healthy controls. The total IIEF was inversely correlated to age of patients (p = 0.013), age at onset (p = 0.043), total, cognitive/mood, gastrointestinal and urinary domains of NMSS, and the cognitive domain of PDQ-39 (p = 0.013). Age was the main predictor (ß = - 0.581, p = 0.006) of SD. Elder patients showed worse sexual functions, stronger correlations to other NMSs, and more impact on HRQoL than younger patients.
Sexual functions are worse among PD male patients with age as the main predictor. SD was associated with worse cognitive/mood and urinary domains of NMSS and has a negative impact on the patients' HRQoL among elder males.
性功能障碍（SD）是帕金森病（PD）常见但报告不足的非运动症状（NMS）。本研究调查了PD男性患者的性功能、其与运动及其他NMS的相关性，以及它们对健康相关生活质量（HRQoL）的影响。
使用国际勃起功能指数（IIEF）评估40例PD男性患者的性功能，并与25名年龄匹配的健康对照者进行比较。使用NMS量表（NMSS）和帕金森病问卷阿拉伯语版（PDQ-39）对患者进行评估。我们比较了年轻（≤55岁）和年长（>55岁）男性的性功能，并测试了性功能与运动、其他NMS及HRQoL之间的相关性。
70%的PD男性患者报告有勃起功能障碍。与健康对照者相比，他们的IIEF总分（p<0.001）及各子评分均显著更差。IIEF总分与患者年龄（p=0.013）、发病年龄（p=0.043）、NMSS的总分、认知/情绪、胃肠道和泌尿领域以及PDQ-39的认知领域呈负相关（p=0.013）。年龄是性功能障碍的主要预测因素（β=-0.581，p=0.006）。年长患者的性功能更差，与其他NMS的相关性更强，对HRQoL的影响比年轻患者更大。
以年龄为主要预测因素的PD男性患者性功能较差。性功能障碍与NMSS中较差的认知/情绪和泌尿领域相关，且对年长男性患者的HRQoL有负面影响。
