Indiana University School of Medicine, 1234 Notre Dame Avenue, South Bend, IN 46617, USA.
Indiana University School of Medicine, 1234 Notre Dame Avenue, South Bend, IN 46617, USA.
Crit Care Clin. 2020 Apr;36(2):189-200. doi: 10.1016/j.ccc.2019.11.001. Epub 2020 Jan 31.
Guided by organ-specific signals in both development and disease response, the heterogeneous endothelial cell population is a dynamic member of the vasculature. Functioning as the gatekeeper to fluid, inflammatory cells, oxygen, and nutrients, endothelial cell communication with its local environment is critical. Impairment of endothelial cell-cell communication not only disrupts this signaling process, but also contributes to pathologic disease progression. Expanding our understanding of those processes that mediate endothelial cell-cell communication is an important step in the approach to treatment of disease processes.
在发育和疾病反应中的器官特异性信号的指导下，异质性的内皮细胞群体是脉管系统的一个活跃成员。内皮细胞作为液体、炎症细胞、氧气和营养物质的守门员，与局部环境的通讯对于其功能至关重要。内皮细胞-细胞通讯的损伤不仅破坏了这个信号传递过程，也导致了病理疾病的进展。扩大我们对介导内皮细胞-细胞通讯的过程的理解，是治疗疾病过程的重要步骤。
