Laboratory of Enzyme Engineering and Microbiology, National Engineering School of Sfax, University of Sfax, Tunisia.
Laboratory of Enzyme Engineering and Microbiology, National Engineering School of Sfax, University of Sfax, Tunisia.
Carbohydr Polym. 2020 May 15;236:116046. doi: 10.1016/j.carbpol.2020.116046. Epub 2020 Feb 24.
Hydrogels properties open up many possibilities for medical applications. In the present study, protein drug insulin was selected as a model drug to test the in vitro release behavior of hydrogels based on blue crab chitosan (Cs) and red marine macroalga Falkenbergia rufolanosa polysaccharide (FRP). The FRP/Cs composed hydrogels were characterized in terms of structural, morphological, thermal and antioxidant properties. Data revealed that FRP addition enhanced the water holding capacity and the water uptake percentages, as well as the textural behavior. Moreover, the prepared hydrogels are simultaneous sensitive to pH, ionic strength and temperature as demonstrated in the swelling ratio test. Additionally, hydrogels at pH 1.2 PBS underwent greater degradation, compared to samples immersed in pH 7.4 PBS. Similarly, the kinetics of insuline release, through the FRP/Cs composed hydrogels exhibited higher released amounts in acidic systems. Through this study, the prepared hydrogels provided suitable and promising microenvironment in drugs delivery.
水凝胶的特性为医学应用开辟了许多可能性。在本研究中，选择蛋白质药物胰岛素作为模型药物，以测试基于蓝蟹壳聚糖（Cs）和红色海洋大型海藻 Farkenbergia rufolanosa 多糖（FRP）的水凝胶的体外释放行为。从结构、形态、热学和抗氧化特性方面对 FRP/Cs 组成的水凝胶进行了表征。数据表明，FRP 的添加提高了水保持能力和吸水率以及质构性能。此外，如溶胀比测试所示，所制备的水凝胶对 pH 值、离子强度和温度同时敏感。此外，与在 pH 7.4 PBS 中浸泡的样品相比，在 pH 1.2 PBS 中的水凝胶经历了更大的降解。同样，通过 FRP/Cs 组成的水凝胶，胰岛素的释放动力学在酸性体系中表现出更高的释放量。通过这项研究，所制备的水凝胶在药物输送中提供了合适且有前景的微环境。
