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[胎盘植入谱系障碍:法国一家三级妇产医院的管理与发病率]

[Placenta accreta spectrum disorder: Management and morbidity in a French type-3 maternity].

作者信息

Chevalier G, Devisme L, Coulon C

机构信息

Département de gynécologie obstétrique, centre hospitalier et universitaire de Lille, Lille, France.

Département d'anatomopathologie, centre hospitalier et universitaire de Lille, Lille, France.

出版信息

Gynecol Obstet Fertil Senol. 2020 Jun;48(6):500-505. doi: 10.1016/j.gofs.2020.03.010. Epub 2020 Mar 12.

Abstract

OBJECTIVES

Placenta accreta spectrum disorder (PASD) is a rare obstetrical pathology, however its incidence is increasing. Morbidity associated with PASD is still high. Even if hysterectomy is considered to be the reference standard treatment, the conservative treatment by leaving the placenta in situ is now an approved option. The objective was to describe management and morbidity of patients with PASD, during the decade, in our French high-level maternity.

METHODS

It was a retrospective study of management and morbidity of PASD in our department between 2007 and 2017.

RESULTS

Forty-six PASD cases were admitted in our center. Thirty-three (71.7%) had a prenatal suspicion of PASD. Conservative treatment was considered for 22 patients (47.8%). It was successful in 12 cases (54.5%). Thirty-four (73.9%) had a primary hysterectomy, eight (17.3%) had a delayed hysterectomy, four (8.6%) had a uterine conservation. Primary Morbidity included 28 blood transfusions, 12 bladder injuries, 1 ureteral injury and 13 transfers to intensive care unit. Secondary morbidity after conservative treatment included two Hemorrhages (16.6%), five endometritis (41.6%) and three disseminated intravacular coagulations (25%).

CONCLUSIONS

Morbidity associated with this pathology is severe. Conservative treatment became an option for PASD. Thanks to a better antenatal diagnosis, it can be proposed to more women. Morbidity seems the same as other centers. Our rate of primary and secondary hysterectomy is higher than other centers. Conservative treatment seems an effective option for women who desire to preserve their fertility to avoid peripartum hysterectomy and its related morbidity and consequences on fertility.

摘要

目的

胎盘植入谱系障碍(PASD)是一种罕见的产科病理情况,但其发病率正在上升。与PASD相关的发病率仍然很高。即使子宫切除术被认为是参考标准治疗方法,但现在保留胎盘原位的保守治疗也是一种认可的选择。目的是描述在我们法国的高级别产科中心,十年来PASD患者的管理及发病率情况。

方法

这是一项对我们科室2007年至2017年期间PASD管理及发病率的回顾性研究。

结果

我们中心收治了46例PASD病例。33例(71.7%)产前怀疑患有PASD。22例患者(47.8%)考虑进行保守治疗。其中12例(54.5%)成功。34例(73.9%)进行了初次子宫切除术,8例(17.3%)进行了延迟子宫切除术,4例(8.6%)保留了子宫。主要发病率包括28次输血、12例膀胱损伤、1例输尿管损伤以及13例转入重症监护病房。保守治疗后的次要发病率包括2例出血(16.6%)、5例子宫内膜炎(41.6%)和3例弥散性血管内凝血(25%)。

结论

与这种病理情况相关的发病率很严重。保守治疗成为PASD的一种选择。由于产前诊断更好,更多女性可以选择保守治疗。发病率似乎与其他中心相同。我们的初次和二次子宫切除率高于其他中心。对于希望保留生育能力以避免围产期子宫切除术及其相关发病率和对生育影响的女性来说,保守治疗似乎是一种有效的选择。

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