Ji Qiang, Zhao Yun, Liu Huan, Yang Ye, Wang YuLin, Ding WenJun, Xia LiMin, Wei Lai, Wang ChunSheng
Department of Cardiovascular Surgery, Zhongshan Hospital Fudan University.
Shanghai Municipal Institute for Cardiovascular Diseases.
Int Heart J. 2020 Mar 28;61(2):201-208. doi: 10.1536/ihj.19-311. Epub 2020 Mar 14.
This single-center study aimed to evaluate the incidence of deep sternal wound infection (DSWI) following skeletonized bilateral internal mammary artery (BIMA) harvest in a Chinese cohort. Using propensity score matching, this study also provided a present-day assessment of the impacts of skeletonized BIMA grafting versus skeletonized single internal mammary artery (SIMA) grafting on early outcomes.From January 2014 to December 2017, 2403 eligible patients were entered into either a BIMA group (n = 368) or a SIMA group (n = 2035). The incidence of DSWI was recorded. Analysis of early outcomes was further performed for propensity score-matched (1:1) cohorts.The BIMA group received a similar incidence of DSWI as did the SIMA group (1.6% versus 0.9%, P = 0.247). No significant differences between subgroup diabetic-BIMA, subgroup nondiabetic-BIMA, subgroup diabetic-SIMA, and subgroup nondiabetic-SIMA were found regarding the incidence of DSWI (2.0%, 1.4%, 1.0%, and 0.7%, respectively; P > 0.05 between groups). After matching, treatment type (skeletonized BIMA grafting versus skeletonized SIMA grafting) was not an independent risk factor for postoperative DSWI (OR = 1.309, 95% CI 0.897-2.714, P = 0.704) or predictors of other early outcomes. Additionally, the two matched groups shared similar early outcomes (including postoperative DSWI), regardless of whether or not the merger with diabetes (all P > 0.05).Skeletonized BIMA harvest as compared with skeletonized SIMA harvest was not associated with an increased risk of DSWI, regardless of whether or not the merger with diabetes. Patients with skeletonized BIMA grafting received similar surgical mortality and major postoperative morbidity as did matched patients with skeletonized SIMA grafting.
这项单中心研究旨在评估中国人群中双侧胸廓内动脉骨骼化采集后深部胸骨伤口感染(DSWI)的发生率。通过倾向评分匹配,本研究还对双侧胸廓内动脉骨骼化移植与单支胸廓内动脉骨骼化移植对早期结局的影响进行了当代评估。2014年1月至2017年12月,2403例符合条件的患者被纳入双侧胸廓内动脉组(n = 368)或单支胸廓内动脉组(n = 2035)。记录DSWI的发生率。对倾向评分匹配(1:1)的队列进一步进行早期结局分析。双侧胸廓内动脉组DSWI的发生率与单支胸廓内动脉组相似(1.6%对0.9%,P = 0.247)。在DSWI发生率方面,糖尿病双侧胸廓内动脉亚组、非糖尿病双侧胸廓内动脉亚组、糖尿病单支胸廓内动脉亚组和非糖尿病单支胸廓内动脉亚组之间未发现显著差异(分别为2.0%、1.4%、1.0%和0.7%;组间P > 0.05)。匹配后,治疗类型(双侧胸廓内动脉骨骼化移植与单支胸廓内动脉骨骼化移植)不是术后DSWI的独立危险因素(OR = 1.309,95%CI 0.897 - 2.714,P = 0.704),也不是其他早期结局的预测因素。此外,两个匹配组的早期结局相似(包括术后DSWI),无论是否合并糖尿病(所有P > 0.05)。与单支胸廓内动脉骨骼化采集相比,双侧胸廓内动脉骨骼化采集与DSWI风险增加无关,无论是否合并糖尿病。接受双侧胸廓内动脉骨骼化移植的患者与接受单支胸廓内动脉骨骼化移植的匹配患者的手术死亡率和术后主要发病率相似。