Kazin E M, Reshenin A M
Probl Endokrinol (Mosk). 1988 Sep-Oct;34(5):56-9.
The disturbance of glucocorticoid balance in early postnatal ontogenesis (17-19 days) as a result of prednisolone administration was shown to lead to partial suppression of circadian adrenocortical activity in adult rats. Circadian rhythm of FFA in these groups of animals was undetectable and circadian acrophase of blood glucose concentration changes while diurnal urine periodicity remained unchanged. Diurnal rhythm of locomotor activity in prednisolone-pretreated tars was characterized by later onset of increasing its activity and shorter duration.
结果表明，在出生后早期发育阶段（17 - 19天）给予泼尼松龙导致糖皮质激素平衡紊乱，会致使成年大鼠的昼夜肾上腺皮质活动受到部分抑制。在这些动物组中，游离脂肪酸（FFA）的昼夜节律无法检测到，血糖浓度变化的昼夜高峰相位改变，而昼夜尿周期保持不变。泼尼松龙预处理的跗骨动物的运动活动昼夜节律特点是活动增加的起始时间延迟且持续时间缩短。
