[用于椎间盘退变中髓核再生的水凝胶研究进展]
[Research progress of hydrogel used for regeneration of nucleus pulposus in intervertebral disc degeneration].
作者信息
Shi Kun, Huang Yong, Huang Leizhen, Wang Jingcheng, Wang Yuhan, Feng Ganjun, Liu Limin, Song Yueming
机构信息
Departmen of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2020 Mar 15;34(3):275-284. doi: 10.7507/1002-1892.201907092.
Abstract
OBJECTIVE
To summarize the research progress of hydrogels for the regeneration and repair of degenerative intervertebral disc and to investigate the potential of hydrogels in clinical application.
METHODS
The related literature about the role of hydrogels in intervertebral disc degeneration especially for nucleus pulposus was reviewed and analyzed.
RESULTS
Hydrogels share similar properties with nucleus pulposus, and it plays an important role in the regeneration and repair of degenerative intervertebral disc, which can be mainly applied in nucleus pulposus prosthesis, hydrogel-based cell therapy, non-cellular therapy, and tissue engineering repair.
CONCLUSION
Hydrogels are widely used in the regeneration and repair of intervertebral disc, which provides a potential treatment for intervertebral disc degeneration.
摘要
目的
总结水凝胶在退变椎间盘再生修复方面的研究进展，并探讨水凝胶在临床应用中的潜力。
方法
回顾并分析有关水凝胶在椎间盘退变尤其是髓核退变中作用的相关文献。
结果
水凝胶与髓核具有相似特性，在退变椎间盘的再生修复中发挥重要作用，主要应用于髓核假体、基于水凝胶的细胞治疗、非细胞治疗及组织工程修复。
结论
水凝胶在椎间盘再生修复中广泛应用，为椎间盘退变提供了一种潜在治疗方法。
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J Orthop Surg Res. 2020 Jan 28;15(1):29. doi: 10.1186/s13018-020-1551-9.
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Melatonin Protects Intervertebral Disc from Degeneration by Improving Cell Survival and Function via Activation of the ERK1/2 Signaling Pathway.褪黑素通过激活 ERK1/2 信号通路提高细胞存活率和功能来保护椎间盘免于退变。
Oxid Med Cell Longev. 2019 Dec 2;2019:5120275. doi: 10.1155/2019/5120275. eCollection 2019.
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Lessons learned from intervertebral disc pathophysiology to guide rational design of sequential delivery systems for therapeutic biological factors.从椎间盘病理生理学中吸取的教训，指导治疗性生物因子序贯递释系统的合理设计。
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