[伤口诱导的毛囊新生：成年哺乳动物毛囊再生的新视角]
[Wound-induced hair follicle neogenesis: a new perspective on hair follicles regeneration in adult mammals].
作者信息
Liu Pengcheng, Tan Qiuwen, Jiang Yanlin, Lü Qing
机构信息
Department of Breast Surgery, Clinical Research Center for Breast Disease, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
Department of Breast Surgery, Clinical Research Center for Breast Disease, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China;Laboratory of Stem Cell and Tissue Engineering, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2020 Mar 15;34(3):393-398. doi: 10.7507/1002-1892.201905102.
OBJECTIVE
To explore the research progress of the cell sources and related signaling pathways of the wound-induced hair follicle neogenesis (WIHN) in recent years.
METHODS
The literature related to WIHN in recent years was reviewed, and the cell sources and molecular mechanism were summarized and discussed.
RESULTS
Current research shows that WIHN is a rare regeneration phenomenon in the skin of adult mammals, with multiple cell origins, both hair follicle stem cells and epithelial stem cells around the wound. Its molecular mechanism is complicated, which is regulated by many signaling pathways. Besides, the process is closely related to the immune response, the immunocytes and their related cytokines provide suitable conditions for this process.
CONCLUSION
There are still many unsolved problems on the cellular origins and molecular mechanisms of the WIHN. Further study on the mechanisms will enhance the understanding of adult mammals' hair follicle regeneration and may provide new strategy for functional healing of the human skin.
目的
探讨近年来伤口诱导毛囊新生（WIHN）的细胞来源及相关信号通路的研究进展。
方法
回顾近年来与WIHN相关的文献，总结并讨论其细胞来源及分子机制。
结果
目前的研究表明，WIHN是成年哺乳动物皮肤中一种罕见的再生现象，具有多种细胞起源，包括毛囊干细胞和伤口周围的上皮干细胞。其分子机制复杂，受多种信号通路调控。此外，该过程与免疫反应密切相关，免疫细胞及其相关细胞因子为这一过程提供了适宜条件。
结论
WIHN的细胞起源和分子机制仍有许多未解决的问题。对其机制的进一步研究将加深对成年哺乳动物毛囊再生的理解，并可能为人类皮肤的功能性愈合提供新策略。
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