伤口诱导性毛发新生：脱发与伤口再生新疗法开发的途径
Wound-Induced Hair Neogenesis: A Portal to the Development of New Therapies for Hair Loss and Wound Regeneration.
作者信息
Oak Allen S W, Cotsarelis George
机构信息
Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
出版信息
Cold Spring Harb Perspect Biol. 2023 Feb 1;15(2):a041239. doi: 10.1101/cshperspect.a041239.
Abstract
Adult mammals retain the remarkable ability to regenerate hair follicles after wounding. Wound-induced hair neogenesis (WIHN) in many ways recapitulates embryogenesis. The origin of the stem cells that give rise to a nascent hair follicle after wounding and the role of mesenchymal cells and signaling pathways responsible for this regenerative phenomenon are slowly being elucidated. WIHN provides a potential therapeutic window for manipulating cell fate by the introduction of factors during the wound healing process to enhance hair follicle formation.
摘要
成年哺乳动物在受伤后仍保留着显著的毛囊再生能力。伤口诱导的毛发新生（WIHN）在许多方面重现了胚胎发育过程。受伤后形成新生毛囊的干细胞来源以及间充质细胞和负责这种再生现象的信号通路的作用正逐渐被阐明。WIHN为在伤口愈合过程中通过引入因子来操纵细胞命运以增强毛囊形成提供了一个潜在的治疗窗口。
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