两种新的倍半萜类化合物来自真菌的培养物。
Two new sesquiterpenes from cultures of the fungus .
机构信息
Engineering and Technology Research Center of Liupanshan Resources, College of Chemistry and Chemical Engineering, Ningxia Normal University, Guyuan 756000, China.
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
出版信息
J Asian Nat Prod Res. 2021 Apr;23(4):348-352. doi: 10.1080/10286020.2020.1737857. Epub 2020 Mar 14.
Two new tremulane-type sesquiterpenes, irlactin L () and irlactin M () were isolated from cultures of the fungus , together with one known compound, 6-hydroxy-2,6-dimethyloct-7-enoic acid (). Their structures were elucidated by spectroscopic data analysis. Compounds were tested for their cytotoxicities against five human cancer cell lines and for their inhibitory activities against isozymes of 11-hydroxysteroid dehydrogenases (11-HSD).[Formula: see text].
从真菌 的培养物中分离得到两种新的震颤烷型倍半萜，irlactin L () 和 irlactin M ()，以及一种已知化合物 6-羟基-2,6-二甲基辛-7-烯酸 ()。通过光谱数据分析阐明了它们的结构。测试了化合物 对五种人癌细胞系的细胞毒性以及对 11-羟甾体脱氢酶 (11-HSD) 同工酶的抑制活性。[公式：见文本]。
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