Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí, Itajaí, SC, Brazil.
Instituto de Investigaciones Fármaco Bioquímicas -IIFB, Universidad Mayor de San Andrés - UMSA, Bolivia.
Nat Prod Res. 2021 Nov;35(22):4876-4880. doi: 10.1080/14786419.2020.1739676. Epub 2020 Mar 16.
Parasitoses are very common throughout the world, generating serious consequences for public health. Leishmaniosis and giardiasis are examples of fairly recurrent, but neglected diseases. Several higher plants have demonstrated promising activity against the parasites. The aim of this study was to evaluate the biological activity of extracts, fractions and isolated compounds from the leaves and stems of two Brazilian plants: and (Myrtaceae) against and . XTT and the fluorimetric method were used to for this evaluation, respectively. Cytotoxicity was evaluated against HeLa cells. The results demonstrated that chloroform fractions of and pinostrobin presented the most pronounced antiparasitic activity, with the CLF-stems being the most effective against and . Pinostrobin also presented activity against . Therefore, stems and pinostrobin may be considered possible targets for the continuity of studies against other parasites.
寄生虫病在全球非常普遍，对公共卫生造成严重后果。利什曼病和贾第虫病就是相当常见但被忽视的疾病的例子。一些高等植物已被证明对寄生虫具有良好的活性。本研究旨在评估巴西两种植物的叶和茎的提取物、馏分和分离化合物对 和 的生物活性。分别使用 XTT 和荧光法进行评估。对 HeLa 细胞进行了细胞毒性评估。结果表明， 和 的氯仿馏分以及松柏醇具有最显著的抗寄生虫活性，其中茎氯仿馏分对 和 最为有效。松柏醇也对 具有活性。因此， 茎和松柏醇可能被认为是针对其他寄生虫的研究的潜在目标。
