Section of Critical Care, Department of Medicine, University of Montreal, Montreal, Canada.
Section of Neurosurgery, Department of Clinical Neurosciences, University of Calgary, Calgary, Canada.
Can J Neurol Sci. 2020 Jul;47(4):551-556. doi: 10.1017/cjn.2020.54. Epub 2020 Mar 16.
In traumatic brain injury (TBI), future integration of multimodal monitoring of cerebral physiology and high-frequency signal processing techniques, with advanced neuroimaging, proteomic and genomic analysis, provides an opportunity to explore the molecular pathways involved in various aspects of cerebral physiologic dysfunction in vivo. The main issue with early and rapid discovery in this field of personalized medicine is the expertise and complexity of data involved. This brief communication highlights the CAnadian High-Resolution Traumatic Brain Injury (CAHR-TBI) Research Collaborative, which has been formed from centers with specific expertise in the area of high-frequency physiologic monitoring/processing, and outlines its objectives.
在创伤性脑损伤 (TBI) 中，未来将对脑生理的多模态监测和高频信号处理技术进行整合，结合先进的神经影像学、蛋白质组学和基因组分析，为探索活体中与脑生理功能障碍各个方面相关的分子途径提供了机会。在个性化医学这一领域，早期快速发现的主要问题在于所涉及的数据的专业性和复杂性。本简讯重点介绍了加拿大高分辨率创伤性脑损伤 (CAHR-TBI) 研究协作组，该协作组由在高频生理监测/处理领域具有专业知识的中心组成，并概述了其目标。
