Chen Yunhui, Han Pingping, Dehghan-Manshadi Ali, Kent Damon, Ehtemam-Haghighi Shima, Jowers Casey, Bermingham Michael, Li Tong, Cooper-White Justin, Dargusch Matthew S
Centre for Advanced Materials Processing and Manufacturing, School of Mechanical and Mining Engineering, The University of Queensland, St Lucia, Queensland, 4072, Australia; School of Mechanical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, OX11 0FA, UK.
The UQ Centre in Stem Cell Ageing and Regenerative Engineering (UQ-StemCARE), Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, 4072, Australia.
J Mech Behav Biomed Mater. 2020 Apr;104:103691. doi: 10.1016/j.jmbbm.2020.103691. Epub 2020 Feb 10.
Titanium-niobium (Ti-Nb) alloys have great potential for biomedical applications due to their superior biocompatibility and mechanical properties that match closely to human bone. Powder metallurgy is an ideal technology for efficient manufacture of titanium alloys to generate net-shape, intricately featured and porous components. This work reports on the effects of Nb concentrations on sintered Ti-xNb alloys with the aim to establish an optimal composition in respect to mechanical and biological performances. Ti-xNb alloys with 33, 40, 56 and 66 wt% Nb were fabricated from elemental powders and the sintering response, mechanical properties, microstructures and biocompatibility assessed and compared to conventional commercial purity titanium (CPTi). The sintered densities for all Ti-xNb compositions were around 95%, reducing slightly with increasing Nb due to increasing open porosity. Higher Nb levels retarded sintering leading to more inhomogeneous phase and pore distributions. The compressive strength decreased with increasing Nb, while all Ti-xNb alloys displayed higher strengths than CPTi except the Ti-66Nb alloy. The Young's moduli of the Ti-xNb alloys with ≥40 wt% Nb were substantially lower (30-50%) than CPTi. In-vitro cell culture testing revealed excellent biocompatibility for all Ti-xNb alloys comparable or better than tissue culture plate and CPTi controls, with the Ti-40Nb alloy exhibiting superior cell-material interactions. In view of its mechanical and biological performance, the Ti-40Nb composition is most promising for hard tissue engineering applications.
钛铌（Ti-Nb）合金因其优异的生物相容性和与人体骨骼紧密匹配的力学性能，在生物医学应用方面具有巨大潜力。粉末冶金是高效制造钛合金以生产净形、具有复杂特征和多孔部件的理想技术。这项工作报道了铌浓度对烧结Ti-xNb合金的影响，目的是确定在力学和生物学性能方面的最佳成分。由元素粉末制备了含33%、40%、56%和66%（重量）铌的Ti-xNb合金，并对其烧结反应、力学性能、微观结构和生物相容性进行了评估，并与传统商业纯钛（CPTi）进行了比较。所有Ti-xNb成分的烧结密度约为95%，由于开孔率增加，随着铌含量的增加略有降低。较高的铌含量阻碍了烧结，导致相和孔隙分布更加不均匀。抗压强度随着铌含量的增加而降低，除了Ti-66Nb合金外，所有Ti-xNb合金的强度都高于CPTi。铌含量≥40%（重量）的Ti-xNb合金的杨氏模量比CPTi低得多（30-50%）。体外细胞培养测试表明，所有Ti-xNb合金都具有优异的生物相容性，与组织培养板和CPTi对照相当或更好，其中Ti-40Nb合金表现出优异的细胞-材料相互作用。鉴于其力学和生物学性能，Ti-40Nb成分在硬组织工程应用中最具前景。
