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用于金属植入物的负载成骨蛋白的生物活性涂层

Bioactive Coatings Loaded with Osteogenic Protein for Metallic Implants.

作者信息

Gherasim Oana, Grumezescu Alexandru Mihai, Grumezescu Valentina, Andronescu Ecaterina, Negut Irina, Bîrcă Alexandra Cătălina, Gălățeanu Bianca, Hudiță Ariana

机构信息

Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, Romania.

Lasers Department, National Institute for Lasers, Plasma, and Radiation Physics, RO-77125 Magurele, Romania.

出版信息

Polymers (Basel). 2021 Dec 9;13(24):4303. doi: 10.3390/polym13244303.

DOI:10.3390/polym13244303
PMID:34960852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8703935/
Abstract

Osteoconductive and osteoinductive coatings represent attractive and tunable strategies towards the enhanced biomechanics and osseointegration of metallic implants, providing accurate local modulation of bone-to-implant interface. Composite materials based on polylactide (PLA) and hydroxyapatite (HAp) are proved beneficial substrates for the modulation of bone cells' development, being suitable mechanical supports for the repair and regeneration of bone tissue. Moreover, the addition of osteogenic proteins represents the next step towards the fabrication of advanced biomaterials for hard tissue engineering applications, as their regulatory mechanisms beneficially contribute to the new bone formation. In this respect, laser-processed composites, based on PLA, Hap, and bone morphogenetic protein 4(BMP4), are herein proposed as bioactive coatings for metallic implants. The nanostructured coatings proved superior ability to promote the adhesion, viability, and proliferation of osteoprogenitor cells, without affecting their normal development and further sustaining the osteogenic differentiation of the cells. Our results are complementary to previous studies regarding the successful use of chemically BMP-modified biomaterials in orthopedic and orthodontic applications.

摘要

骨传导和骨诱导涂层是增强金属植入物生物力学性能和骨整合的有吸引力且可调节的策略，能对骨与植入物界面进行精确的局部调节。基于聚乳酸（PLA）和羟基磷灰石（HAp）的复合材料被证明是调节骨细胞发育的有益基质，是骨组织修复和再生的合适机械支撑。此外，添加成骨蛋白是制造用于硬组织工程应用的先进生物材料的下一步，因为它们的调节机制有助于新骨形成。在这方面，本文提出基于PLA、Hap和骨形态发生蛋白4（BMP4）的激光加工复合材料作为金属植入物 的生物活性涂层。纳米结构涂层被证明具有促进骨祖细胞粘附、活力和增殖的卓越能力，且不影响其正常发育，并进一步维持细胞的成骨分化。我们的结果补充了先前关于在骨科和正畸应用中成功使用化学BMP修饰生物材料的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d9/8703935/18f47c22e55b/polymers-13-04303-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d9/8703935/87f6fc252490/polymers-13-04303-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d9/8703935/07a2c170f050/polymers-13-04303-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d9/8703935/e5a6ac73ce7d/polymers-13-04303-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d9/8703935/e63629a6b477/polymers-13-04303-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d9/8703935/67f0c76024fd/polymers-13-04303-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d9/8703935/0e6c038c242a/polymers-13-04303-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d9/8703935/ff849c292c28/polymers-13-04303-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d9/8703935/18f47c22e55b/polymers-13-04303-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d9/8703935/a46f10c84335/polymers-13-04303-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d9/8703935/7186e18080ce/polymers-13-04303-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d9/8703935/5ec452add3be/polymers-13-04303-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d9/8703935/8baf76995da2/polymers-13-04303-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d9/8703935/87f6fc252490/polymers-13-04303-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d9/8703935/07a2c170f050/polymers-13-04303-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d9/8703935/e5a6ac73ce7d/polymers-13-04303-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d9/8703935/e63629a6b477/polymers-13-04303-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d9/8703935/67f0c76024fd/polymers-13-04303-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d9/8703935/0e6c038c242a/polymers-13-04303-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d9/8703935/ff849c292c28/polymers-13-04303-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d9/8703935/18f47c22e55b/polymers-13-04303-g012.jpg

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