惊恐障碍中血清素受体超敏反应的行为指征。

Behavioral indications for serotonin receptor hypersensitivity in panic disorder.

作者信息

Kahn R S, Wetzler S, van Praag H M, Asnis G M, Strauman T

机构信息

Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY 10467.

出版信息

Psychiatry Res. 1988 Jul;25(1):101-4. doi: 10.1016/0165-1781(88)90163-1.

DOI:10.1016/0165-1781(88)90163-1

PMID:3217461

Abstract

Immediate placebo-corrected behavioral responses to m-chlorophenylpiperazine (MCPP), a selective serotonin agonist, are reported in 11 normal controls, 10 patients with panic disorder, and 10 patients with major depression. Whereas the normal and depressed groups showed no noteworthy behavioral response, panic disorder patients became more anxious, depressed, and hostile, and 60% had panic attacks. These data suggest a hypersensitive postsynaptic serotonin receptor system in some panic disorder patients.

摘要

据报道，11名正常对照者、10名惊恐障碍患者和10名重度抑郁症患者对选择性5-羟色胺激动剂间氯苯哌嗪（MCPP）产生了即时的安慰剂校正行为反应。正常组和抑郁组未表现出明显的行为反应，而惊恐障碍患者变得更加焦虑、抑郁和敌对，60%的患者出现惊恐发作。这些数据表明，一些惊恐障碍患者存在突触后5-羟色胺受体系统过敏。