Branchey M H, Buydens-Branchey L, Lieber C S
Psychiatry Service, VA Medical Center, Bronx, NY 10468.
Psychiatry Res. 1988 Jul;25(1):49-58. doi: 10.1016/0165-1781(88)90157-6.
Alcoholics have been found to show deficits in the P3 component of event-related potentials obtained using information-processing paradigms. However, alcoholic patients form a heterogeneous population. In a study of P3 voltages in subgroups of alcoholics with disorders in mood and aggression control, we observed significant decrements in these voltages in patients with lifelong histories of aggressive behavior. Patients with histories of incarceration for crimes involving physical violence had the lowest P3 amplitudes. The same patients also had a rate of paternal alcoholism significantly higher than that observed in the rest of the population. They could thus be classified as type 2 alcoholics, as a tendency to antisocial behavior and a high genetic loading for alcoholism have been described in this alcoholic subtype. These data could indicate that decrements in P3 amplitude characterize a subgroup of alcoholics with a disordered regulation of aggression. Alternatively, P3 deficits could be associated with some psychopathological conditions in individuals who abuse alcohol rather than with alcoholism, per se.
研究发现，酗酒者在使用信息处理范式获得的事件相关电位的P3成分中表现出缺陷。然而，酗酒患者构成了一个异质性群体。在一项对情绪和攻击控制失调的酗酒亚组的P3电压研究中，我们观察到有终身攻击行为史的患者的这些电压显著降低。因涉及身体暴力犯罪而被监禁的患者的P3波幅最低。同样这些患者的父亲酗酒率明显高于其他人群。因此，他们可被归类为2型酗酒者，因为在这种酗酒亚型中，已描述了反社会行为倾向和酗酒的高遗传负荷。这些数据可能表明，P3波幅降低是攻击调节失调的酗酒亚组的特征。或者，P3缺陷可能与酗酒个体的某些精神病理状况有关，而不是与酗酒本身有关。
