Fishbein D H, Herning R I, Pickworth W B, Haertzen C A, Hickey J E, Jaffe J H
Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224.
Biol Psychiatry. 1989 Oct;26(6):595-611. doi: 10.1016/0006-3223(89)90085-1.
Auditory brainstem evoked response (BAER) and spontaneous electroencephalogram (EEG) were measured in 124 adult male drug abusers. We examined the relationships among psychiatric diagnoses, paper and pencil measures of aggression and hostility, and electrophysiological features. Subjects meeting criteria for antisocial personality disorder (ASP), as defined by DSM-III, were not significantly different from non-ASP subjects for either BAER or spontaneous EEG measures. The more overtly aggressive subjects had significant delays in BAER latency. Aggressive subjects also had more delta activity and less alpha activity in the spontaneous EEG, as have been observed in "psychopaths" and "criminals." Although ASP and aggression are related, these data indicate that aggressiveness may be a separate, albeit overlapping, trait. As both early aggression and a diagnosis of ASP are predictors of later drug use, the findings that only aggression was associated with EEG slowing and brainstem delays may indicate that ASP and aggression make independent contributions to vulnerability to the development of drug abuse.
对124名成年男性药物滥用者进行了听觉脑干诱发电位（BAER）和自发脑电图（EEG）测量。我们研究了精神诊断、纸笔形式的攻击性和敌意测量以及电生理特征之间的关系。根据《精神疾病诊断与统计手册第三版》（DSM - III）定义，符合反社会人格障碍（ASP）标准的受试者在BAER或自发EEG测量方面与非ASP受试者无显著差异。攻击性更明显的受试者BAER潜伏期有显著延迟。攻击性受试者在自发脑电图中也有更多的δ波活动和更少的α波活动，这在“精神病患者”和“罪犯”中也有观察到。虽然ASP与攻击性有关，但这些数据表明攻击性可能是一个独立的特质，尽管存在重叠。由于早期攻击性和ASP诊断都是后期药物使用的预测因素，只有攻击性与EEG减慢和脑干延迟相关的发现可能表明ASP和攻击性对药物滥用易感性有独立的影响。
