Kim Ji Sun, Kang Eun-Sook, Bahk Yong Chun, Jang Sunglee, Hong Kyung Sue, Baek Ji Hyun
Department of Psychiatry, Sooncheonhyang University Cheonan Hospital, Cheonan, South Korea.
Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Front Psychiatry. 2020 Feb 26;11:124. doi: 10.3389/fpsyt.2020.00124. eCollection 2020.
Non-suicidal self-injury (NSSI) is a rapidly increasing mental health problem that requires more clinical attention. In this study, we aimed to explore the biobehavioral markers of NSSI in participants with mood disorders. A total of 45 participants with mood disorders (bipolar I, II, and major depressive disorder) were included in the study. Behavioral impulsivity was measured using the immediate memory task (IMT)/delayed memory task (DMT) and the go-no-go (GNG) tests. Plasma levels of tumor necrosis factor-α (TNF-α), interleukin 1 beta (IL-1 β), and interleukin 6 (IL-6) and resting-state quantitative electroencephalography (qEEG) were measured. The NSSI group had shorter GNG reaction time (GNG-RT) and higher TNF-α levels compared to the non-NSSI group. TNF-α was positively correlated with frontal theta power. In addition, GNG-RT showed a significant positive association with frontal alpha activity. NSSI in mood disorders was associated with increased behavioral impulsivity and greater inflammation. Increased pro-inflammatory cytokines were associated with frontal theta power. Increased inflammation might change major neurotransmitter metabolism, which eventually affects frontal function and decreases response inhibition. Further studies to explore their causal relationship are warranted.
非自杀性自伤（NSSI）是一个迅速增加的心理健康问题，需要更多的临床关注。在本研究中，我们旨在探索情绪障碍参与者中NSSI的生物行为标志物。共有45名情绪障碍（双相I型、II型和重度抑郁症）参与者纳入本研究。使用即时记忆任务（IMT）/延迟记忆任务（DMT）和停止信号（GNG）测试测量行为冲动性。测量血浆肿瘤坏死因子-α（TNF-α）、白细胞介素1β（IL-1β）和白细胞介素6（IL-6）水平以及静息态定量脑电图（qEEG）。与非NSSI组相比，NSSI组的GNG反应时间（GNG-RT）更短，TNF-α水平更高。TNF-α与额叶θ波功率呈正相关。此外，GNG-RT与额叶α活动呈显著正相关。情绪障碍中的NSSI与行为冲动性增加和炎症加剧有关。促炎细胞因子增加与额叶θ波功率有关。炎症加剧可能会改变主要神经递质代谢，最终影响额叶功能并降低反应抑制能力。有必要进行进一步研究以探索它们之间的因果关系。
